Metformin Hydrochloride

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: 1. Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization. 2. Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc. 3. Inhibit hepatic gluconeogenesis and reduce hepatic glucose output. 4. Inhibit the uptake of glucose by intestinal wall cells. 5. Inhibit the biosynthesis and storage of cholesterol and reduce blood triglyceride and total cholesterol levels. Unlike the effect of insulin, this product has no effect on promoting fat synthesis and no obvious hypoglycemic effect on normal people. It generally does not cause hypoglycemia when used alone for type 2 diabetes.

Metformin Hydrochloride

Used for mild diabetes.

1. Common symptoms include: nausea, vomiting, diarrhea, metallic taste in the mouth. 2. Sometimes there is weakness, tiredness, dizziness, and rash. 3. Although the incidence of lactic acidosis is very low, it should be paid attention to. Clinical manifestations include vomiting, abdominal pain, hyperventilation, mental disorder, and increased lactic acid concentration in the blood that cannot be explained by uremia, ketoacidosis or salicylic acid poisoning. 4. It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce megaloblastic anemia, and also cause malabsorption.

1. It is contraindicated for children under 10 years old, people over 80 years old, pregnant and lactating women; 2. It is contraindicated for patients with impaired liver and kidney function or abnormal creatinine clearance; 3. It is contraindicated for patients with heart failure (shock), acute myocardial infarction and other severe heart and lung diseases; 4. It is contraindicated for patients with severe infection or trauma, major surgical operations, clinical hypotension and hypoxia, etc.; 5. It is contraindicated for patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis with or without coma; 6. It is contraindicated for patients with concurrent severe diabetic nephropathy or diabetic fundus lesions; 7. It is contraindicated for alcoholics and patients with uncorrected vitamin B12 and folic acid deficiency; 8. It is contraindicated for patients who need to undergo intravascular injection of iodinated contrast agent examination; 9. It is contraindicated for patients who are allergic to this product.

Precautions for children: Not for use by children under 10 years old. Precautions for pregnancy and lactation: Not for use by pregnant and lactating women. Precautions for the elderly: Not for use by people over 80 years old.

1. When used in combination with insulin, the hypoglycemic effect is enhanced, so the dosage should be adjusted. 2. This product can enhance the anticoagulant effect of anticoagulants (such as warfarin), which may cause bleeding tendency. 3. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dosage of this product should be reduced.

Keep sealed.

Tentatively 24 months.

Shijiazhuang Polee Pharmaceutical Co., Ltd.

• Founded in:

  2006-09-27

• Address:

  Xinzhaidian Industrial Zone, Zhao County

• Tax NO.:

  9113013379416484XR

• Registered Funds:

  21 million yuan

• Website:

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• Email:

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