Metformin Hydrochloride Tablets

This product is a hypoglycemic drug. This product can reduce fasting and postprandial hyperglycemia in patients with type 2 diabetes, and HbAlc can be reduced by 1% to 2%. The mechanism of this product in lowering blood sugar may be: 1. Increase the sensitivity of peripheral tissues to insulin and increase insulin-mediated glucose utilization; 2. Increase the utilization of glucose by non-insulin-dependent tissues, such as the brain, blood cells, renal medulla, intestines, skin, etc.; 3. Inhibit hepatic gluconeogenesis and reduce hepatic glucose output; 4. Inhibit intestinal wall cells from taking up glucose; 5. Inhibit the biosynthesis and storage of cholesterol and reduce blood triglyceride and total cholesterol levels. Unlike the effect of insulin, this product has no effect on promoting fat synthesis, no obvious hypoglycemic effect on normal people, and no effect on type 2 diabetes.

The main ingredient of this product is metformin hydrochloride, and its chemical name is 1,1-dimethylbiguanide hydrochloride.

This product is a white enteric film-coated tablet, which appears white after removing the coating.

It is used for patients with type 2 diabetes who are not satisfied with diet control alone, especially those who are obese and have hyperinsulinemia. This drug not only has the effect of lowering blood sugar, but also has the effect of reducing weight and hyperinsulinemia. It can be effective for patients with poor efficacy of certain sulfonylureas. For example, it is more effective when used in combination with sulfonylurea hypoglycemic drugs, intestinal glycosidase inhibitors or thiazolidinedione hypoglycemic drugs than when used alone. It can also be used for patients treated with insulin to reduce the amount of insulin.

Oral administration: Adults start with 0.25g once, 2-3 times a day, and then adjust the dosage according to blood sugar and urine sugar levels, generally 1g-1.5g per day, and no more than 2g per day. Take half an hour before meals, enteric-coated tablets can reduce gastrointestinal reactions.

1 Gastrointestinal reactions, manifested as loss of appetite, nausea, vomiting, diarrhea, stomach pain, metallic taste in the mouth. 2 Sometimes there is weakness, tiredness, weight loss, dizziness, and rash. 3 Although the incidence of lactic acidosis is very low, it should be paid attention to. Clinical manifestations include vomiting, abdominal pain, hyperventilation, mental disorders, and increased lactic acid concentration in the blood that cannot be explained by uremia, ketoacidosis, or salicylic acid poisoning. 4 It can reduce the intestinal absorption of vitamin B12, reduce hemoglobin, produce megaloblastic anemia, and can also cause malabsorption.

The following conditions should not be used: 1. Type 2 diabetes accompanied by ketosis, acidosis, liver and kidney dysfunction (serum creatinine exceeds 1.5mg/dl), pulmonary insufficiency, heart failure, respiratory failure, acute myocardial infarction, severe infection and trauma, major surgery, and clinical hypotension and hypoxia. 2. Alcoholics, excessive drinkers, dehydration, dysentery, malnutrition, and those who are allergic to this product and biguanides. 3. Diabetes with severe chronic complications (such as diabetic nephropathy, diabetic fundus lesions). 4. Before intravenous pyelography or arterial angiography. 5. Patients with severe heart and lung diseases. 6.

Precautions for children: The maximum daily dose of this product for patients with type 2 diabetes aged 10-16 years is 2000 mg. This product is not recommended for children under 10 years old. Precautions for pregnancy and lactation: This product is not recommended for pregnant women. Lactating women should use this product with caution. If this product must be used, breastfeeding should be stopped. Precautions for the elderly: Elderly patients over 65 years old should use this product with caution and have their renal function checked regularly. The maximum dose is usually not used. This product is not recommended for patients over 80 years old unless their creatinine clearance test shows that their renal function is not reduced.

1. This drug combined with insulin will enhance the hypoglycemic effect, so the insulin dose should be reduced. 2. It can enhance the anticoagulant effect of anticoagulants (such as warfarin), leading to bleeding tendency. 3. If this product is taken with alcoholic beverages, abdominal pain, acidosis and hypothermia may occur. 4. When this product is used in combination with sulfonylureas, it can cause hypoglycemia. 5. Cimetidine can increase the bioavailability of this product and reduce the renal clearance rate, so the dose of this product should be reduced.

Keep tightly closed.

0.25g

24 months.

Jiangxi Huiren Pharmaceutical Co., Ltd.

• Founded in:

  2002-04-03

• Address:

  No. 1266, Huiren Avenue, Xiaolan Economic and Technological Development Zone, Nanchang, Jiangxi

• Tax NO.:

  91360121736373627B

• Registered Funds:

  450 million yuan

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