Tamoxifen Citrate Tablets

Tamoxifen is a non-steroidal anti-estrogen drug. Its structure is similar to that of estrogen, and there are two isomers, Z and E. The two have different physical and chemical properties and physiological activities. The E type has weak estrogen activity, while the Z type has anti-estrogen effects. If there are estrogen receptors (ER) in breast cancer cells, estrogen enters the tumor cells and binds to them, promoting the synthesis of DNA and m-RNA in the tumor cells and stimulating the growth of tumor cells. The Z-isomer of tamoxifen enters the cells, competes with ER for binding, forms a receptor complex, and prevents the effect of estrogen, thereby inhibiting the proliferation of breast cancer cells.

The main ingredient of this product is tamoxifen citrate.

This product is white tablets.

1. To treat recurrent and metastatic breast cancer in women; 2. To be used as an adjuvant treatment for metastatic breast cancer after surgery to prevent recurrence.

Oral administration: 10 mg (1 tablet) each time, twice a day; or 20 mg (2 tablets) each time, twice a day.

Bone and tumor pain may be transiently aggravated at the beginning of treatment, and gradually alleviated with continued treatment. A small number of patients have adverse reactions. Gastrointestinal reactions: loss of appetite, nausea, vomiting, diarrhea; reproductive system: menstrual disorders, amenorrhea, vaginal bleeding, vulvar itching, endometrial hyperplasia, endometrial polyps and endometrial cancer; skin: facial flushing, rash, hair loss. Bone marrow: occasional leukopenia and thrombocytopenia; liver function: occasional abnormalities; eyes: long-term (more than 17 months) and large amounts (240-320 mg per day) use may cause retinopathy or corneal opacity. Rare adverse reactions that require attention: mental confusion, pulmonary embolism (manifested as shortness of breath), thrombosis, weakness, drowsiness.

It is contraindicated for patients with fundus diseases.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: It has an impact on the fetus and is contraindicated for pregnant and lactating women. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

Estrogen can affect the therapeutic effect of this product; antacids, cimetidine, ranitidine, etc. change the pH value in the stomach, causing the enteric coating of this product to decompose prematurely, which has a stimulating effect on the stomach.

Keep in a light-proof and airtight container.

10 mg

24 months

Fuan Pharmaceutical Group Ningbo Team Pharmaceutical Co., Ltd.

• Founded in:

  1992-08-12

• Address:

  No. 366, Anping Road, Zhaobaoshan Street, Zhenhai District, Ningbo City, Zhejiang Province

• Tax NO.:

  91330211144072003N

• Registered Funds:

  415 million yuan

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