Nifedipine Tablets
Function and Efficacy
Nifedipine (NF) inhibits the influx of calcium ions into cells by blocking the membrane transport of calcium ions in myocardial and vascular smooth muscle, causing decreased myocardial contractility and vasodilation. Animal experiments have shown that it reduces myocardial oxygen consumption by reducing myocardial contractility and peripheral vascular resistance; increases oxygen supply to myocardial ischemic sites by dilating coronary vessels and developing collateral circulation; and enhances anti-hypoxia capabilities by inhibiting the consumption of high-energy phosphate compounds.
Ingredients
The main ingredient of this product is nifedipine. Chemical name: 2,6-dimethyl-4 (2-nitrophenyl)-1,,-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester Molecular weight: C17H18N2O6
| Name | Description | Content | CAS NO. | Manufacturer |
|---|---|---|---|---|
| NifedipineIngredients |
By blocking the membrane transport of calcium ions in myocardial and vascular smooth muscle, inhibiting the influx of calcium ions into cells, it causes a decrease in myocardial contractility and vasodilation. Animal experiments have shown that by reducing myocardial contractility and peripheral vascular resistance, myocardial oxygen consumption is reduced; by dilating coronary vessels and developing collateral circulation, the oxygen supply to myocardial ischemic sites is increased; by inhibiting the consumption of high-energy phosphate compounds, the ability to resist hypoxia is enhanced. More |
21829-25-4 | 75 |
Appearance
This product is a film-coated tablet, which appears yellow after removing the coating.
Indication
No data yet
Usage and Dosage
1. The dose of nifedipine should be gradually adjusted according to the patient's tolerance and control of angina pectoris. Overdose of nifedipine can lead to hypotension. 2. Start with a small dose. The general starting dose is 10 mg/time, orally 3 times a day; the commonly used maintenance dose is 10-20 mg/time orally 3 times a day. For some patients with obvious coronary artery spasm, it can be used up to 20-30 mg/time, 3-4 times a day. The maximum dose should not exceed 120 mg/day. If the condition is urgent, 10 mg/time can be chewed or taken sublingually. Depending on the patient's response to the drug, decide to give the drug again. 3. It usually takes 7-14 days to adjust the dose. If the patient's symptoms are obvious and the condition is urgent, the dose adjustment period can be shortened. According to the patient's response to the drug, the frequency of attacks and sublingual nitroglycerin
Adverse Reactions
1. Peripheral edema is common after taking the drug (peripheral edema is related to the dose, the incidence is 4% when taking 60 mg/day, and 12.5% when taking 120 mg/day); dizziness; headache; nausea; fatigue and facial flushing (10%). Transient hypotension (5%), usually does not require discontinuation of the drug (transient hypotension is related to the dose, the incidence is 2% when taking 60 mg/day, and the incidence is 5% when taking 120 mg/day). Some patients experience angina pectoris, which may be related to the hypotensive reaction. Palpitations; nasal congestion; chest tightness; shortness of breath; constipation; diarrhea; gastrointestinal cramps; abdominal distension; skeletal muscle inflammation; joint stiffness; muscle spasms; mental tension; tremors; nervousness; sleep disorders; blurred vision; imbalance, etc. (2%) can also be seen. Syncope (0.5%), which will no longer occur if the dose is reduced or used in combination with other anti-anginal drugs. 2. Rare anemia; leukopenia; thrombocytopenia; purpura; allergic hepatitis; gingival hyperplasia; depression; paranoia; instant blindness at peak blood concentration; erythromelalgia; antinuclear antibody positive arthritis, etc. ([0.5%). 3. Possible serious adverse reactions: Myocardial infarction and congestive heart failure occurred at a rate of 4%; pulmonary edema occurred at a rate of 2%; arrhythmia and conduction block occurred at a rate of less than 0.5% each. 4. Allergic hepatitis, rash, and even exfoliative dermatitis may occur in patients allergic to this product.
Precautions
It is contraindicated in patients allergic to nifedipine.
Special Population Medication
Precautions for children: Not clear yet. Precautions for pregnancy and lactation: 1. No detailed clinical research data. Nifedipine is clinically used for pregnant women with hypertension. 2. Nifedipine can be secreted into breast milk, so lactating women should stop taking the drug or stop breastfeeding. Precautions for the elderly: The half-life of nifedipine is prolonged in the elderly, so pay attention to adjusting the dose when using it.
Drug Interactions
1. Nitrates. They are well tolerated when used in combination with this product to control angina attacks. 2. β-receptor blockers. Most patients have good tolerance and efficacy when using this product in combination, but some patients may induce and aggravate hypotension, heart failure and angina. 3. Digitalis. This product may increase the concentration of digoxin in the blood, suggesting that the blood concentration of digoxin should be monitored when using it for the first time, adjusting the dose or stopping it. 4. When drugs with high protein binding rates such as dicoumarols, phenytoin sodium, quinidine, quinine, warfarin, etc. are used with this product, the free concentrations of these drugs often change. 5. When cimetidine is used with this product, the peak plasma concentration of this product increases, so pay attention to adjusting the dose.
Storage
seal.
Packaging Specification
10mg(film-coated tablet)
Validity Period
24 months
Manufacturer
Changzhou Kangpu Pharmaceutical Co., Ltd.
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Founded in:
1979-12-01 -
Address:
No. 6, Jingde East Road, Qianhuang Town, Wujin District -
Tax NO.:
91320412250816627K -
Registered Funds:
20 million yuan -
Website:
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Email: