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Tetracycline tablets

Function and Efficacy

This product is a broad-spectrum antibacterial agent with bactericidal effect at high concentrations. In addition to common Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria, most Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria and spirochetes are also sensitive to this product. This product is more effective against Gram-positive bacteria than Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to tetracycline. This product has good antibacterial effect on Gram-negative bacteria such as Vibrio, Yersinia pestis, Brucella, Campylobacter, Yersinia, etc., has no antibacterial activity against Pseudomonas aeruginosa, and has certain antibacterial effect on some anaerobic bacteria, but it is far less than...

Ingredients

The main ingredient of this product is tetracycline, whose chemical name is 6-methyl-4-(dimethylamino)-3,6,10,12,12α-pentahydroxy-1,11-dioxo-1,4,4α,5,5α,6,11,12α-octahydro-2-naphthacenecarboxamide.

Name Description Content CAS NO. Manufacturer
TetracyclineIngredients

This product is a broad-spectrum antibacterial agent with bactericidal effect at high concentrations. In addition to common Gram-positive bacteria, Gram-negative bacteria and anaerobic bacteria, most Rickettsia, Mycoplasma, Chlamydia, atypical mycobacteria and spirochetes are also sensitive to this product. This product is better than Gram-positive bacteria for Gram-negative bacteria, but Enterococcus is resistant to it. Others such as Actinomycetes, Bacillus anthracis, Listeria monocytogenes, Clostridium, Nocardia, etc. are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant gonococci are also resistant to tetracycline. This product has good antibacterial effect on Gram-negative bacteria such as Vibrio, Yersinia pestis, Brucella, Campylobacter, Yersinia, etc., has no antibacterial activity against Pseudomonas aeruginosa, and has certain antibacterial effect on some anaerobic bacteria.

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60-54-8 25

Appearance

This product is a yellow tablet or sugar-coated tablet.

Indication

1 This product is used as the first choice or optional drug for the following diseases: (1) Rickettsial diseases, including epidemic typhus, endemic typhus, Rocky Mountain fever, scrub typhus and Q fever. (2) Mycoplasma infections. (3) Chlamydia infections, including psittacosis, venereal diseases, lymphoedema, nonspecific urethritis, salpingitis, cervicitis and trachoma. (4) Relapsing fever. (5) Brucellosis. (6) Cholera. (7) Tularemia. (8) Plague. (9) Chancroid. It should be used in combination with aminoglycosides to treat brucellosis and plague. 2 Due to the current common pathogens

Usage and Dosage

Oral administration, the usual dosage for adults is 0.25-0.5g at a time, once every 6 hours. The usual dosage for children over 8 years old is 25-50mg/kg each time, once every 6 hours. The course of treatment is generally 7-14 days, while mycoplasma pneumonia and brucellosis require about 3 weeks.

Adverse Reactions

1 Gastrointestinal symptoms such as nausea, vomiting, upper abdominal discomfort, bloating, diarrhea, etc., occasionally cause reports of pancreatitis, esophagitis and esophageal ulcers, mostly occurring in patients who are bedridden immediately after taking the drug. 2 This product can cause hepatotoxicity, usually fatty liver degeneration. Pregnant women and patients with pre-existing renal impairment are prone to hepatotoxicity, but hepatotoxicity can also occur in patients without the above conditions. Tetracycline-induced pancreatitis can also occur simultaneously with hepatotoxicity, and the patient does not have primary liver disease. 3 Allergic reactions: mostly maculopapular rash and erythema, a small number of patients may experience urticaria, angioedema, allergic purpura, pericarditis, and worsening of the rash of systemic lupus erythematosus, exfoliative dermatitis is not common. Occasionally allergic

Precautions

It is contraindicated for patients who are allergic to tetracyclines.

Special Population Medication

Precautions for children: When using this product during tooth development (mid- and late-stage pregnancy, infants and children under 8 years old), tetracycline can form stable calcium compounds in any bone tissue, leading to yellowing of permanent teeth, enamel hypoplasia and bone growth inhibition, so this product should not be used in children under 8 years old. Precautions for pregnancy and lactation: This product can enter the fetus through the placental barrier and deposit in the calcium area of teeth and bones, causing fetal tooth discoloration, poor enamel regeneration and inhibition of fetal bone growth. This type of drug has teratogenic effects in animals, so it should not be used by pregnant women. At the same time, pregnant women are particularly sensitive to the hepatotoxic reaction of tetracycline and should avoid using this type of drug. This product can be secreted from breast milk, and the concentration in breast milk is high, which has the potential to cause serious adverse reactions to infants. When using it, breastfeeding women should suspend breastfeeding. Precautions for the elderly: Elderly patients are often accompanied by renal impairment, so the dosage needs to be adjusted. The use of this product is prone to cause hepatotoxicity, so elderly patients should use it with caution.

Drug Interactions

1 When used together with antacids such as sodium bicarbonate, the absorption of this product may be reduced and its activity may be reduced due to the increase in gastric pH. Therefore, antacids should not be taken within 1 to 3 hours after taking this product. 2 Drugs containing metal ions such as calcium, magnesium, and iron may form insoluble complexes with this product, reducing its absorption. 3 When used in combination with the general anesthetic methoxyflurane, its nephrotoxicity may be enhanced. 4 When used in combination with strong diuretics such as furosemide, renal damage may be aggravated. 5 When used in combination with other hepatotoxic drugs (such as anti-tumor chemotherapy drugs), liver damage may be aggravated. 6 Lipid-lowering drugs such as colestylamine or colestipol may affect the absorption of this product.

Storage

Keep away from light, sealed and stored in a dry place.

Packaging Specification

0.125 g (125,000 units)

Manufacturer

Taosheng Pharmaceutical Co., Ltd.

  • Founded in:

    2005-02-17
  • Address:

    No. 6 Hongwu Avenue, Industrial Park, Mingguang City, Anhui Province
  • Tax NO.:

    91341182771135528U
  • Registered Funds:

    50 million yuan
  • Website:

  • Email:

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