Spironolactone tablets

Aldosterone antagonist. It can inhibit the sodium retention, potassium excretion and water retention caused by the action of aldosterone on the distal renal tubule. When the blood aldosterone concentration is not high, the effect of this product is also weak. On the contrary, when secondary aldosterone increases, the effect of this drug is significant.

The main ingredient of this product: spironolactone. Chemical name: 17β-hydroxy-3-oxo-7a-(acetylthio)-17a-pregnane-4-ene-21-carboxylic acid Y-lactone.

White flakes.

1. Edema diseases: It is used in combination with other diuretics to treat edema diseases such as congestive edema, ascites caused by liver cirrhosis, and renal edema. The purpose is to correct the increased secondary aldosterone secretion associated with the above diseases and counteract the potassium excretion effect of other diuretics. It is also used to treat idiopathic edema. 2. Hypertension: It is used as an auxiliary drug for the treatment of hypertension. 3. Primary aldosteronism: Spironolactone can be used for the diagnosis and treatment of this disease. 4. Prevention of hypokalemia: It is used in combination with thiazide diuretics to enhance the diuretic effect and prevent hypokalemia.

1. Adults ① For the treatment of edema, take 40-120 mg daily, divided into 2-4 times, for at least 5 consecutive days. Adjust the dose as appropriate later. ② For the treatment of hypertension, start with 40-80 mg daily, divided into 2 times, for at least 2 weeks, and adjust the dose as appropriate later. It is not suitable to be used in combination with angiotensin-converting enzyme inhibitors to avoid increasing the chance of hyperkalemia. ③ For the treatment of primary aldosteronism, the daily dose for patients before surgery is 100-400 mg, divided into 2-4 times. For patients who are not suitable for surgery, a smaller dose is used for maintenance. ④ For the diagnosis of primary aldosteronism. For long-term tests, take 400 mg daily, divided into 2-4 times, for 3-4 consecutive weeks. For short-term tests, take 400 mg daily, divided into 2-4 times, for 4 consecutive days. The elderly are more sensitive to this drug, so the initial dose should be smaller. 2. For the treatment of edema in children, start with 1-3 mg/kg per day or 30-90 mg/㎡ per body surface area, taken once or in 2-4 doses, and adjust the dose as appropriate after 5 consecutive days. The maximum dose is 3-9 mg/kg or 90-270 mg/㎡ per day.

1. Hyperkalemia: It is especially likely to occur in patients with renal insufficiency or when taking potassium supplements. 2. Long-term and large-scale use may cause breast enlargement and impotence in men; irregular menstruation and hirsutism in women, which disappear after stopping the drug. 3. Hyponatremia: It is less common. 4. Gastrointestinal reactions: Nausea, vomiting, stomach pain, diarrhea, etc. 5. Occasionally, headache and rash may occur.

Contraindicated in patients with hyperkalemia.

Precautions for children: For the treatment of edema in children, start with 1-3 mg/kg per day or 30-90 mg/m2 per body surface area, taken as a single dose or in 2-4 doses. Adjust the dose as appropriate after 5 consecutive days. The maximum dose is 3-9 mg/kg or 90-270 mg/m2 per day. Precautions for pregnancy and lactation: Use with caution in pregnant and lactating women. Precautions for the elderly: Elderly people are more likely to develop hyperkalemia and excessive diuresis when taking the drug.

(1) Adrenal cortical hormones, especially those with strong mineralocorticoid effects, adrenocorticotropic hormone can weaken the diuretic effect of this drug and antagonize its potassium-retaining effect. (2) Estrogen can cause water and sodium retention, thereby weakening the diuretic effect of this drug. (3) Non-steroidal anti-inflammatory analgesics, especially indomethacin, can reduce the diuretic effect of this drug, and increase renal toxicity when used together. (4) Sympathomimetic drugs reduce the antihypertensive effect of this drug. (5) Dopamine enhances the diuretic effect of this drug. (6) When used in combination with drugs that cause a decrease in blood pressure, both the diuretic and antihypertensive effects are enhanced. (7) When used in combination with the following drugs, the chance of hyperkalemia increases, such as potassium-containing drugs, stored blood (containing potassium 30mmol/L, such as stored

Sealed, store in a dry place.

20 mg

30 months

Anhui Guozheng Pharmaceutical Co., Ltd.

• Founded in:

  1999-01-16

• Address:

  No. 6, Xiyou Road, Yanhe Community, Changqing Street, Baohe District, Hefei City

• Tax NO.:

  91340100711742115T

• Registered Funds:

  53.5 million yuan

• Email:

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