Cimetidine tablets

1 Pharmacology: It mainly acts on H2 receptors on gastric parietal cells, competitively inhibiting histamine, inhibiting basal gastric acid secretion, and also inhibiting gastric acid secretion stimulated by food, pentagastrin, caffeine and insulin; 2 Toxicology: Acute LD50: 3190-3280 mg/kg for oral administration to mice and 5840-7500 mg/kg for oral administration to rats. Subacute and chronic toxicity tests on rats and dogs have shown that this product has a mild anti-androgenic effect, causing a decrease in the weight of the prostate and seminal vesicles and milk secretion, but this disappears after drug withdrawal. It has no mutagenic, carcinogenic, or teratogenic effects, and is also non-dependent and non-tolerant.

Each tablet of this product contains the main ingredient, 0.2 g of imipenem, and the auxiliary materials are starch, dextrin, magnesium stearate, and sodium carboxymethyl starch.

This product is a white tablet or a light blue or light green tablet with a colorant, or a film-coated tablet.

Used to treat duodenal ulcer, gastric ulcer, reflux esophagitis, stress ulcer and Zollinger-Ellison syndrome.

1. For the treatment of duodenal ulcer or pathological hypersecretion, 0.2~0.4g once, 4 times a day, after meals and before bedtime, or 0.8g once, once before bedtime; 2. For the prevention of ulcer recurrence, 0.4g once, before bedtime; 3. For patients with renal insufficiency, the dosage is reduced to 0.2g once, once every 12 hours; 4. For elderly patients, the dosage is reduced as appropriate. 5. Children: Orally, 5~10mg/Kg per body weight, 2~4 times a day.

1. Common adverse reactions include diarrhea, dizziness, fatigue, headache and rash; 2. This product has a mild anti-androgen effect. When the dosage is large (more than 1.6g per day), it can cause male breast development, female galactorrhea, loss of libido, impotence, decreased sperm count, etc., which will disappear after stopping the drug; 3. This product can pass the blood-cerebrospinal fluid barrier and has certain neurotoxicity. Mental disorders are occasionally seen, which are more common in the elderly, young children, and seriously ill patients. They can recover within 48 hours after stopping the drug. When treating gastrointestinal complications of alcoholics, delirium tremens may occur, which is similar to alcohol withdrawal syndrome; 4. Rare adverse reactions of this product include: allergic reactions, fever, arthralgia, myalgia, granulocytopenia, thrombocytopenia, interstitial nephritis, liver toxicity, bradycardia, tachycardia, etc.

It is contraindicated for pregnant and lactating women.

Precautions for children: Children should use the product under the guidance of a physician. Precautions for pregnancy and lactation: Pregnant and lactating women are prohibited. Precautions for the elderly: Elderly patients should use the product under the guidance of a physician.

1. When used in combination with antacids, it has a synergistic effect in relieving pain in duodenal ulcers, but the absorption of cimetidine may be reduced, so it is generally not recommended. If it must be used in combination with antacids, the two should be taken at least 1 hour apart; 2. Taking metoclopramide (Metoclopramide) with this product at the same time can reduce the blood concentration of this product, and the dose of this product needs to be appropriately increased; 3. Since sucralfate needs to be hydrolyzed by gastric acid to work, this product inhibits gastric acid secretion, and the combination of the two may reduce the efficacy of sucralfate; 4. This product inhibits the oxidative metabolic pathway catalyzed by cytochrome P450 and can reduce liver blood flow. Therefore, when used in combination with other drugs, this product can reduce their metabolism and enhance their pharmacological activity or toxicity. These drugs include: benzodiazepines; coumarin anticoagulants; phenytoin sodium or other hydantoin drugs; propranolol, metoprolol, metronidazole; theophylline, caffeine, aminophylline; verapamil (Isapamil); quinidine; polycaine, tricyclic antidepressants; opioids, etc.; 5 Because this product increases the pH value of gastric juice, when used in combination with tetracycline, it may cause the dissolution rate of tetracycline to decrease, absorption to decrease, and the effect to weaken (but the hepatic enzyme inhibitory effect of this product may increase the blood concentration of tetracycline); if used in combination with aspirin, the opposite result will occur, and the effect of aspirin may be enhanced; 6 Combination with ketoconazole may interfere with the latter's absorption and reduce its antifungal activity, but taking some acidic beverages at the same time can avoid the above changes; 7 Combination of this product with captopril may cause mental symptoms; 8 Because this product has a myoneural blocking effect similar to that of aminoglycoside antibiotics, combined use may cause respiratory depression or respiratory arrest.

Keep sealed.

0.8g

36 months

Jilin Hengjin Pharmaceutical Co., Ltd.

• Founded in:

  2000-11-09

• Address:

  No. 1385, Beihuan West Road, Meihekou City, Jilin Province (Business location: No. 15, Yongjun Road, Tiebei Street, Meihekou City)

• Tax NO.:

  912205817248769480

• Registered Funds:

  171.3 million yuan

• Email:

  Log in to view