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Glucose injection

Function and Efficacy

Glucose is one of the main sources of heat for the human body. Each gram of glucose can produce 4 calories (16.7 kJ) of heat energy, so it is used to supplement heat. Treat hypoglycemia. When glucose and insulin are intravenously infused together, potassium ions are required for the synthesis of glycogen, so potassium ions enter the cells and the blood potassium concentration decreases, so it is used to treat hyperkalemia. Rapid intravenous push of hypertonic glucose injection has a tissue dehydrating effect and can be used as a tissue dehydrating agent. In addition, glucose is the main substance for maintaining and regulating the osmotic pressure of peritoneal dialysis fluid.

Ingredients

The main ingredient and chemical name of this product is: glucose. Molecular formula: C6H12O6H2O Molecular weight: 198.17

Name Description Content CAS NO. Manufacturer
GLUCOSEIngredients

It is one of the main sources of heat for the human body. Each gram of glucose can produce 4 calories (16.7 kJ) of heat energy, so it is used to supplement heat. Treat hypoglycemia. When glucose and insulin are intravenously infused together, potassium ions are required for the synthesis of glycogen, so potassium ions enter the cells and the blood potassium concentration decreases, so it is used to treat hyperkalemia. Rapid intravenous push of hypertonic glucose injection has a tissue dehydrating effect and can be used as a tissue dehydrating agent. In addition, glucose is the main substance for maintaining and regulating the osmotic pressure of peritoneal dialysis fluid.

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Appearance

This product is a colorless or almost colorless clear liquid with a sweet taste.

Indication

1. Replenish energy and body fluids, used for insufficient food intake or large body fluid loss (such as vomiting, diarrhea, etc.) caused by various reasons, total intravenous nutrition, starvation ketosis. 2. Hypoglycemia; 3. Hyperkalemia; 4. Hypertonic solution used as tissue dehydrating agent; 5. Preparation of peritoneal dialysis solution; 6. Drug diluent; 7. Intravenous glucose tolerance test; 8. For the preparation of GIK (polarization solution) solution.

Usage and Dosage

1. When patients eat less or cannot eat for some reason, they can generally be given 25% glucose injection intravenously and replenish body fluids at the same time. The amount of glucose is calculated according to the required heat energy. 2. Glucose is the most important energy supply substance for total intravenous nutrition therapy. In non-protein heat energy, the ratio of glucose to fat heat supply is 2:1. The specific dosage depends on the clinical heat needs. According to the needs of fluid replacement, glucose can be prepared into different concentrations of 25% to 50%. If necessary, insulin is added. For every 5 to 10g of glucose, 1 unit of regular insulin is added. Since the normal use of hypertonic glucose solution is more irritating to the vein and requires infusion of fat emulsion, large vein drip is generally used. 3. Hypoglycemia, severe cases can first be given 20 to 40ml of 50% glucose injection intravenous push. 4. Starvation ketosis, severe cases should be given 5% to 25% glucose injection intravenous drip, and 100g of glucose per day can basically control the condition. 5. Dehydration isotonic dehydration is given 5% glucose injection intravenous drip. 6. Hyperkalemia can be treated with 10-25% injection solution, and 1 unit of regular insulin can be added for every 2-4g of glucose infusion to reduce serum potassium concentration. However, this therapy only allows extracellular potassium ions to enter cells, and the total potassium content in the body remains unchanged. If potassium excretion measures are not taken, hyperkalemia may still recur. 7. Rapid intravenous injection of 20-50ml of tissue dehydration hypertonic solution (generally 50% glucose injection solution) is used. However, the effect is short-lived. Clinically, attention should be paid to preventing hyperglycemia, and it is rarely used at present. When used to adjust the osmotic pressure of peritoneal dialysis fluid, 20ml of 50% glucose injection solution, i.e. 10g of glucose, can increase the osmotic pressure of 1L peritoneal dialysis fluid by 55mOsm/kgH2O.

Adverse Reactions

1. Phlebitis, which occurs when hypertonic glucose injection is dripped. If a large vein is used for dripping, the incidence of phlebitis will decrease. 2. Extravasation of high-concentration glucose injection can cause local swelling and pain. 3. Reactive hypoglycemia: It is prone to occur when combined with excessive use of insulin, the original tendency to hypoglycemia, and the sudden cessation of total intravenous nutrition therapy. 4. Hyperglycemic non-ketotic coma: It is more common in patients with diabetes, stress, the use of large amounts of glucocorticoids, and uremia peritoneal dialysis when hypertonic glucose solutions and total nutrition therapy are given intraperitoneally. 5. Electrolyte imbalance. Hypokalemia, hyponatremia, and hypophosphatemia are prone to occur when glucose is simply supplemented for a long time. 6. Those with original heart failure. 7. Hyperkalemia, which occasionally occurs in patients with type 1 diabetes when high-concentration glucose is used.

Precautions

1. Uncontrolled diabetic ketoacidosis; 2. Hyperglycemia in non-ketotic hyperosmolar state.

Special Population Medication

Precautions for children: Too fast or too much fluid replacement can cause palpitations, arrhythmias, and even acute left heart failure. Precautions for pregnancy and lactation: Too much glucose injection during delivery can stimulate fetal insulin secretion and cause postpartum hypoglycemia in infants. Precautions for the elderly: Too fast or too much fluid replacement can cause palpitations, arrhythmias, and even acute left heart failure.

Drug Interactions

Not yet clear.

Storage

Keep tightly closed.

Packaging Specification

20ml:10g

Validity Period

36 months

Manufacturer

Shanxi JINXIN DOUBLE-CRANE Pharmaceutical Co., Ltd.

  • Founded in:

    2001-12-14
  • Address:

    Sanlidun, North of Xia County, Yuncheng City, Shanxi Province
  • Tax NO.:

    911408287281430205
  • Registered Funds:

    164.191 million yuan
  • Website:

  • Email:

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