Mosapride Citrate Tablets

This product is a selective 5-hydroxytryptamine (5-HT4) receptor agonist. It promotes the release of acetylcholine by stimulating the 5-HT4 receptors of the gastrointestinal cholinergic interneurons and myenteric plexus, thereby enhancing the motility of the upper gastrointestinal tract (stomach and small intestine). Studies have shown that this product has the effect of promoting gastric and duodenal motility and accelerating gastric emptying. Rat studies have shown that repeated administration of this product for one week weakens its effect on promoting gastric emptying. In long-term (104 weeks in rats and 92 weeks in mice) administration studies in rodents, the incidence of liver cell adenomas and thyroid cell adenomas increased at doses of 30~100 mg/kg/day (equivalent to 100~300 times the clinically recommended dose).

The main ingredient of this product is: Mosapride citrate. Its chemical name is: 4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2-morpholinyl]methyl}benzamide citrate. Molecular formula: C21H25ClFN3O3C6H8O72H2O

This product is a white film-coated tablet, which appears white after removing the coating.

This product is a gastrointestinal prokinetic agent, mainly used for functional dyspepsia accompanied by gastrointestinal symptoms such as heartburn, belching, nausea, vomiting, early satiety, upper abdominal distension, etc.; it can also be used for gastroesophageal reflux disease, diabetic gastroparesis and gastric dysfunction in patients with partial gastrectomy.

Oral administration, 5 mg at a time, three times a day, before meals.

The main symptoms are diarrhea, abdominal pain, dry mouth, rash, fatigue, dizziness, etc. Occasionally, eosinophilia, elevated triglycerides, aspartate aminotransferase (GOT), alanine aminotransferase (GPT), alkaline phosphatase (AKP), and γ-glutamyl transpeptidase (GGT) are seen.

It is contraindicated for those who are allergic to this product.

Precautions for children: The safety of this product for children has not been confirmed (no clinical use experience). Precautions for pregnancy and lactation: Because its safety has not been determined, this product should be avoided. Precautions for the elderly: Elderly people should be carefully observed when taking the drug, and if side effects are found, appropriate treatment should be taken immediately, such as reducing the dosage.

The effect of this product may be weakened when used in combination with anticholinergic drugs (such as atropine sulfate, butylscopolamine bromide, etc.).

Sealed and stored at room temperature.

5 mg

24 months