Hexamethylmelamine capsules

This product is a pyrimidine antimetabolite drug, which mainly inhibits dihydrofolate reductase, interferes with folic acid metabolism, and selectively inhibits the synthesis of DNA, RNA and protein. It is a cycle-specific drug and has no cross-resistance with alkylating agents.

The main ingredients of this product are: Hexamethylmelamine Chemical name: 2,4,6-tris(dimethylamino)-s-triazine Molecular formula: C9H18N6 Molecular weight: 210.28

This product is in the form of capsules.

This product is used for combined chemotherapy of ovarian cancer, SCLC, malignant lymphoma, and endometrial cancer, and is particularly effective for ovarian cancer and SCLC.

Oral administration: 10-16 mg/kg per day, divided into four doses, 21 days as a course of treatment or 6-8 mg/kg per day, 90 days as a course of treatment. In the combined regimen, the recommended total dose is 150-200 mg/m2 per body surface area, for 14 consecutive days, with good tolerance. Taking it 1-1.5 hours after a meal or before bedtime can reduce gastrointestinal reactions.

1. Severe nausea and vomiting are dose-limiting toxicities. Bone marrow suppression is mild to moderate, with a prominent decrease in leukocytosis. It usually occurs one week after treatment and reaches its lowest point in 3 to 4 weeks. 2. Central or peripheral neurotoxicity occurs after long-term use and is a dose-limiting toxicity. It can be alleviated or disappear after stopping the drug for 4 to 5 months. 3. Occasionally, there may be hair loss, cystitis, rash, itching, weight loss, etc.

It is contraindicated for those who are allergic to this product.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: Pregnant and lactating women should use this product with caution. Precautions for the elderly: Elderly patients over 65 years old should reduce the dosage as appropriate.

Combination with monoamine oxidase inhibitors and antidepressants can cause severe orthostatic hypotension and should be used with caution. Combination with metoclopramide can cause dystonia. Simultaneous use with vitamin B6 may reduce peripheral neurotoxicity.

Keep away from light and store in sealed container.

100mg

24 months

Shanxi Angsheng Pharmaceutical Co., Ltd.

• Founded in:

  2001-09-10

• Address:

  Shanxi Province Lucheng City Ecological Economic Park

• Tax NO.:

  91140400731890596X

• Registered Funds:

  38.9 million yuan

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