Imatinib mesylate
1 Inquiries
220127-57-1
Pharmaceutical Grade
99%
SHANGHAI
50kg/as customer's requirment
Yes
2060-10-27
Imatinib mesylate
-
Product Description
-
Seller Information
-
Inquiry History
-
Description
Properties
Melting point:214-224°C
storage temp. -20°C Freezer
solubility H2O: soluble10mg/mL, clear
form White solid
color white to beige
InChIKeyYLMAHDNUQAMNNX-UHFFFAOYSA-NECHEMI Editorial ReferenceImatinib Mesylate is a tyrosine kinases inhibitor that inhibits c-Kit, Bcr-Abl, and PDGFR (IC50=100 nM) tyrosine kinases.
Imatinib methanesulfonate is a methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours. It has a role as an antineoplastic agent, an apoptosis inducer, a tyrosine kinase inhibitor and an anticoronaviral agent. It contains an imatinib.|Imatinib Mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Inhibition of the bcr-abl TK results in decreased proliferation and enhanced apoptosis in malignant cells of Philadelphia-positive (Ph+) hematological malignancies such as CML and ALL; effects on c-kit TK activity inhibit mast-cell and cellular proliferation in those diseases overexpressing c-kit, such as mastocytosis and gastrointestinal stromal tumor (GIST).|A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors.Basic Info-
Product Name:
Imatinib mesylate
Other Name:Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,methanesulfonate (1:1);Benzamide,4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-,monomethanesulfonate;Imatinib mesilate;Imatinib mesylate;CGP 57148B;STI 571;Glivec;Gleevac;Gleevec;1-Methyl-4-(4-((4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)carbamoyl)benzyl)piperazine methanesulfonate;Mitinab;ST 571
CAS No.:220127-57-1
Molecular Formula:C29H31N7O.CH4O3S
InChIKeys:InChIKey=YLMAHDNUQAMNNX-UHFFFAOYSA-N
Molecular Weight:589.70800
Exact Mass:589.24700
EC Number:606-892-3
UNII:8A1O1M485B
NSC Number:716051
DSSTox ID:DTXSID9040502
NCI Thesaurus Code:C1687
Color/Form:White to off white to brownish or yellowish tinged crystalline powder
ATC Code:L01XE01
HScode:2933990090
Categories:
Characteristics-
PSA:
149.03000
XLogP3:5.19690
Appearance:white crystalline powder .
Density:0.858 g/mL at 25 °C(lit.)
Melting Point:146-148 °C
Boiling Point:754.9ºC at 760 mmHg
Flash Point:410.3ºC
Refractive Index:n20/D 1.401(lit.)
Water Solubility:In water, >100 g/l @ pH 4.2; 49 mg/l @ pH 7.4
Experimental Properties:Lipophilic at pH 7.4|Molecular weight: 493.60; melting point: 211-213 °C; pKa1: 8.07; pKa2: 3.73; pKa3: 2.56; pKa 4: 1.52 /Imatinib/
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Imatinib mesylate
-
Location:
No.21,HuanCheng West Road ,AnQing City ,Anhui Province,China
-
Payment Terms:
D/P,L/C,D/A
-
Total Annual Revenue:
$1 million-$2.5 million
-
Total Employees:
11-50
-
Year of Establishment:
2009
Company Certificates-
business license
-
ISO9001
ANHUI HAIKANG PHARMACEUTICAL CO.,LTD. was established in 2009 in Anqing City, Anhui Province. It is located along the north bank of mid and lower reaches of the Yangtze River. Enjoying favorable geographic superiorities and convenient transportation infrastructure: such as highway, high speed railway, airport, inland shipping container terminal and so on. By plane, it takes just 1 hour to Shanghai, 2 hours to Guangzhou or Beijing; by high speed train it takes 2 hours to reach Nanjing, 4 hours to Shanghai, 6.5 hours Beijing.Since founded the company has been committed to the production, sales and export of chemical raw materials of pharmaceutical APIs and intermediates, while as well as other services of product customization, process improvement, achievement transfer,etc.
The company covers an area of 28000 square meters. We invested 80 million Yuan to set up 3 synthesis workshops and 3 purification workshops, whose annual output value is over hundred million Yuan, and their profits and taxes are over 20 million Yuan. All our productions are in strict accordance with GMP standard and we have established a well-equipped R & D center.
Haikang currently employs 50 people. 2 of them are of doctoral degree, 6 of master degree,1 researcher returned from overseas and all the rest employees have at least college education. We have close cooperation with Zhejiang University of Technology, University of Science and Technology of China and Anhui University of Chinese Medicine ,etc. We have an academic advisors team consisting of experts and professors who have well background of medical profession and ample experience in pharmacy developing and marketing. It is a united, hard-working, courageous, rigorous and innovative team of elites.
Through years of unremitting efforts Haikang has made remarkable achievements in the R&D and production of anti-virus, antidiabetic series APIs and intermediates. The main products are ganciclovir, valganciclovir hydrochloride, valaciclovir HCL, silodosin, repaglinide, sitagliptin, imatinib and their intermediates. We have established long and stable relationship with nearly 100 domestic and international pharmaceutical manufacturers and research institutes.
To deal with increasingly fierce competition and challenges of economic globalization, Haikang adheres to the business philosophy of “Customer is First, Technology is Leading, Quality is Everything, Honesty for Development” and insists on developing scientifically, globally and diversely. Relying on our existing advantages, we focus on the integration of various resources, and actively optimize the system of decision-making, management and service. We keep up with the pace of the newest R&D trend in and outside China; keep continuous innovation to develop high-tech, market prospective products to satisfy different needs from different customers. While pursuing economic benefits, Haikang has also committed to spare no efforts to advanced environmental management. It is always a mission and moreover a responsibility for Haikang to take care of people’s health and protect the environment.
We have confidence in our future and looking forward to having sincere, win-win and brilliant cooperation with you!
-
-
Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
Bangladesh
Imatinib Mesylate
2100 G Oct 27, 2025 Post an enquiry for this product
More from this Seller
-
-
-
Ganciclovir Mono-O-acetate 99%
Industrial Grade / 99%
-
-
-
-
Sugammadex sodium 99%
Pharmaceutical Grade / 99%
$1/MT FOB
-
-
-
-
4-[(4-methyl-1-piperazinyl)methyl]-, hydrochloride 99%
Pharmaceutical Grade / 99%
$1/MT FOB
-
-
-
-
(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazo 99%
Pharmaceutical Grade / 99%
$1/MT FOB
-
-
-
-
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car 99%
Pharmaceutical Grade / 99%
$2/MT FOB
-
-
-
-
Sitagliptin 99%
Industrial Grade / 99%
-