Tricalcium phosphate

310.17700

309.79500

231-840-8

K4C08XP666

DTXSID1049803

White amorphous powder|White, crystalline powder|Two crystalline modifications are known, the high temperature alpha- and the low-temperature beta-form, transition temperature 110 °C.|Rhombohedral crystals /Whitlockite/

A - Alimentary tract and metabolism

3103900000

192.12000

0.772

White aqueous suspension

3.14 g/cm³

1670 °C

158ºC at 760 mmHg

1.63

2.5 mg/100 g water at 25 deg C

2-8ºC

LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

Odorless

Tasteless

DECOMP IN HOT WATER

Water soluble.

Salts, Basic

Some calcium phosphates form acid solutions in water. These may attack metals with formation of flammable hydrogen gas, which may collect in enclosed spaces (USCG, 1999).

NONH for all modes of transport

3

R36/37/38

S26; S36; S24/25; S22

Xi

STABLE IN AIR /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/

P280, P305+P351+P338, P310

H318

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substances classified as stabilizers, when migrating from food-packaging material shall incl ... calcium phosphate.|Calcium phosphate (mono-, di-, and tribasic) used as a multiple purpose GRAS food substance in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/|Calcium phosphate (mono-, di-, tribasic) used as a dietary supplement in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/|Calcium phosphate (mono-, di-, and tribasic) used as a nutrient in food for human consumption is generally recognized as safe when used in accordance with good manufacturing practice. /Calcium phosphate (mono-, di-, and tribasic)/|For more FDA Requirements (Complete) data for TRICALCIUM PHOSPHATE (6 total), please visit the HSDB record page.

Optimal Calcium Uptake. Current Bibliographies in Medicine 94-4. Public Services Division/National Library of Medicine. 775 citations from January, 1990-April, 1994. Available from: http://www.nlm.nih.gov/pubs/cbm/calcium.html|WHO; Diseases Caused by Phosphorus and Its Toxic Compounds; Early Detection of Occupational Diseases pg 53-62 (1986). Review of diseases and health related effects resulting from exposure to phosphorus or phosphorus cmpd.

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 545 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]|P280, P305+P351+P338, and P310|Aggregated GHS information provided by 36 companies from 2 notifications to the ECHA C&L Inventory.

Neutralizing Agents for Acids and Caustics: Flush with water (USCG, 1999)

Dust mask, goggles, and gloves (USCG, 1999)

IDENTIFICATION AND USE: White amorphous, or crystaline powder. It is odorless and tasteless. It is practically insoluble in alcohol, and acetic acid, and soluble in dilute hydrochloric acid, and nitric acid. Slightly soluble in water. It is used in the manufacture of fertilizers, phosphate compounds, manufacture of milk glass, polishing and dental powders, porcelains, pottery, enameling; clarifying sugar syrups; in animal feeds; as noncaking agent; in textile industry. It is used as a stabilizer in plastics; in meat tenderizers; in food as a buffer and used in medical applications as a calcium replenisher. It veterinary medicine it is used as a dietary supplement and an antacid. It is used in the manufacture of luminescent materials. HUMAN EXPOSURE AND TOXICITY: Tricalcium phosphate is not irritating and toxic doses by ingestion would have to be more than 2 g/kg. Skin sensitization is unusual. Aspiration or inhalation could cause chemical pneumonitis. Implantation of material will cause foreign body reaction. Tricalcium phosphate is contraindicated in treatment of hypocalcemia with hyperphosphatemia which may occur in hypoparathyroidism and renal failure. ANIMAL STUDIES: Tricalcium phosphate exhibited no teratogenic effect in developing chicken embryos.

Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.|USUALLY OBTAINED FROM ANIMAL BONES WHICH CONTAIN ABOUT 80% OF TRIBASIC CALCIUM PHOSPHATE. /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/

For use as an over the counter calcium and phosphate supplement, antacid, or a source of calcium and phosphate in toothpaste.|FDA Label

... CHIEFLY USED AS GASTRIC ANTACID ... VALUABLE SOURCE OF CALCIUM ION, ESPECIALLY WHEN IT IS DESIRED TO SUPPLY BOTH CALCIUM & PHOSPHORUS. /FORMER USE/|... /THIS/ ORALLY ADMIN CALCIUM ... /SALT/ CAN BE USED IN TREATMENT OF MILD & LATENT HYPOCALCEMIC TETANY & FOR MAINTENANCE THERAPY ... .|AN EXCELLENT SOURCE OF BOTH CALCIUM AND PHOSPHORUS USEFUL IN SUPPLEMENTING CALCIUM INTAKE, AS, FOR EXAMPLE, DURING PREGNANCY & LACTATION, OR AS SOURCE OF CALCIUM IN DISEASES OF CALCIUM DEFICIENCY.|Calcium replenisher|For more Therapeutic Uses (Complete) data for TRICALCIUM PHOSPHATE (6 total), please visit the HSDB record page.

... CONTRAINDICATED IN TREATMENT OF HYPOCALCEMIA WITH HYPERPHOSPHATEMIA, WHICH MAY OCCUR IN HYPOPARATHYROIDISM AND RENAL FAILURE.|Ceramic implant materials, including tricalcium phosphate, are biocompatible and are currently being used to restore alveolar bone loss resulting from periodontal disease, endodontic infections, and residual alveolar ridge resorption. However, use of such a material in this case led to persistent infection and additional bone destruction. Thus, the use of a ceramic implant material to accelerate periapical bone repair is not recommended in areas where a chronic bacterial infection is present.

Calcium phosphate reacts with acid in the stomach to raise the pH. In toothpaste it provides a source of calcium and phosphate ions to support remineralization of the teeth. As a supplement it provides a source of calcium and phospate, both of which are important ions in bone homeostasis.

/Ortho/ phosphate is absorbed from, and to a limited extent secreted into, the gastrointestinal tract. Transport of phosphate from the gut lumen is an active, energy-dependent process that is modified by several factors. ... Vitamin D stimulates phosphate absorption, an effect reported to precede its action on calcium ion transport. In adults, about two thirds of the ingested phosphate is absorbed, and that which is absorbed is almost entirely excreted into the urine. In growing children, phosphate balance is positive. Concentrations of phosphate in plasma are higher in children than in adults. This "hyperphosphatemia" decreases the affinity of hemoglobin for oxygen and is hypothesized to explain the physiological "anemia" of childhood. /Phosphates/

A defect in phosphate metabolism occurs in a variety of diseases. ... Rickets ... Osteomalacia ... Primary or Secondary Hyperparathyroidism ... Chronic Renal Failure. /Phosphates/

The phosphate ions in calcium phosphate likely react with hydrochloric acid in the stomach to neutralize the pH. In toothpaste and in systemic circulation, calcium phosphate provides a source of calcium and phosphate ions to support remineralization of the teeth and bone homeostasis respectively. The increase in plasma calcium reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH). Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.

Inhalation of MCP or DCP may cause irritation of upper respiratory tract; prolonged inhalation of concentrated pyrophosphate may cause a deposit of TCP in the lungs. Ingestion of large quantities of any form of calcium phosphate may cause nausea, vomiting, cramps, and diarrhea; MCP may also be corrosive to membranes of mouth, throat, and gastrointestinal tract. Local irritation of the eyes may result from contact with any of these phosphates; prolonged or repeated exposure to MCP may lead to chronic conjunctivitis. Contact with skin by MCP may cause local irritation or chronic dermatitis; prolonged or repeated contact with concentrated aqueous slurries of DCP may cause local irritation. (USCG, 1999)

INHALATION: move to clean air; see physician in case of persistent coughing, expectoration, chest pain, or shortness of breath. INGESTION: get medical attention quickly; induce vomiting by giving large amounts of water or warm salty water, or by tickling back of patient's throat; continue until vomitus is clear; follow with milk, eggs, or olive oil to soothe stomach. EYES: immediately flush with large quantities of running water for at least 15 min., holding eyelids apart to insure thorough flushing of eyes and lids; do not attempt to neutralize with chemical agents; get medical attention quickly; if physician is (USCG, 1999)

... NOT IRRITATING & TOXIC DOSES BY INGESTION WOULD HAVE TO BE IN EXCESS OF 2 G/KG. ... SKIN SENSITIZATION IS UNUSUAL. ASPIRATION OR INHALATION ... COULD CAUSE CHEM PNEUMONITIS. IMPLANTATION ... WILL CAUSE FOREIGN BODY REACTION. /CALCIUM PHOSPHATE/

calcium phosphate

ESSENTIALLY 100% OF TRICALCIUM PHOSPHATE IS USED IN THE CRUDE FORM (DEFLUORINATED PHOSPHATE ROCK) AS A MINERAL SUPPLEMENT IN LIVESTOCK & POULTRY FEEDS; SMALL AMOUNTS OF REFINED TRICALCIUM PHOSPHATE ARE USED AS FOOD ADDITIVES TO CONTROL THE PH IN DOUGHS & LARD, & AS A YEAST NUTRIENT IN FLOUR (1972)

Grade: it is about 96% pure, usually containing an excess of calcium oxide.|Grades: granular; technical; chemically pure: a grade designation signifying a minimum of impurities, but not 100% purity; National Formulary; pure precipitated; Food Chemicals Codex.

Adhesive manufacturing|Phosphoric acid, calcium salt (1:?): ACTIVE|Food, beverage, and tobacco product manufacturing|Phosphoric acid, calcium salt (2:3): ACTIVE|... VARIABLE MIXT OF CALCIUM PHOSPHATES ... APPROX COMPOSITION 10CAO.3P2O5.H2O (1004.64). IT CONTAINS AN AMT OF PHOSPHATE (PO4) EQUIVALENT TO NOT LESS THAN 90.0% OF TRIBASIC CALCIUM PHOSPHATE ... CALCULATED ON THE IGNITED BASIS. /TRIBASIC CALCIUM PHOSPHATE, NATIONAL FORMULARY/|... CAN INACTIVATE METALLIC IONS, WHICH ARE CAPABLE OF INTERFERING WITH NECESSARY FOOD-PROCESSING REACTIONS ... /INACTIVATION IS/ EITHER BY PPTN & REMOVING THEM FROM INTERFERENCE WITH DESIRED FOOD-PROCESSING REACTIONS OR BY COMPLEXING & MAINTAINING THEM IN SOL, BOUND STATE. /PHOSPHATES/|Occurs in nature as the minerals: oxydapatit, voelicherite, whitlockite.|Commercial tricalcium phosphate consists mainly of hydroxyapitite, Ca5(PO4)3OH.

Food additives|Agrochemicals -> Rodenticides|Cosmetics -> Abrasive; Anticaking; Antiplaque; Buffering; Bulking; Opacifying; Oral care; Viscosity controlling

Food Additives -> EMULSIFIER; HUMECTANT; SEQUESTRANT;|Food Additives -> ACIDITY_REGULATOR; ANTICAKING_AGENT;