Silodosin
1 Inquiries
160970-54-7
Pharmaceutical Grade
99%
SHANGHAI
1kg/2.5kg Fiber Drum
Yes
2071-07-17
Imatinib mesylate
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Product Details
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Seller Information
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Inquiry History
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Description
Properties
alpha D25 -14.0° (c = 1.01 in methanol)
Boiling point:601.4±55.0 °C(Predicted)
Density 1.249±0.06 g/cm3(Predicted)
pka14.85±0.10(Predicted)ECHEMI Editorial ReferenceWhite SolidSilodosin, an a1A adrenoceptor (a1A-AR) antagonist selective for prostatic receptors, was launched as an oral treatment for dysuria associated with benign prostatic hypertrophy (BPH). The regulation of smooth muscle tone in the bladder neck and prostate is thought to be primarily mediated by a1A-AR. Blockade of these receptors can cause smooth muscle relaxation in these areas, resulting in improved symptoms and urinary flow rates. Conversely, a1B-AR are largely located on vascu
Silodosin is an indolecarboxamide.|Silodosin is an α1-adrenoceptor antagonist that is selective for the prostate. Silodosin is for symptomatic treatment of benign prostatic hyperplasia. FDA approved Oct 9, 2008.|Silodosin is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.|Silodosin is a selective alpha-1a adrenergic antagonist used in the therapy of benign prostatic hypertrophy. Silodosin is associated with a low rate of serum aminotransferase elevations and to rare instances of clinically apparent acute liver injury.|Silodosin is an orally available, alpha-1 adrenoreceptor (alpha-1a) selective antagonist that can be used to relieve symptoms of benign prostate hyperplasia (BPH). Upon administration, silodosin selectively binds alpha-1a receptors located in the human prostate and bladder with high affinity and blocks signaling pathways mediated by alpha-1a. Blockade of these receptors causes smooth muscle relaxation, lowers intraurethral pressure, and results in improved urine flow and a reduction in the symptoms of BPH, such as difficulty with urinating, painful urination, urinary frequency and incomplete bladder emptying. In addition, silodosin may be used to improve lower urinary tract symptoms, which can occur after receiving radiation therapy for prostate cancer.Basic Info-
Product Name:
Silodosin
Other Name:1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-;1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-,(R)-;2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide;KMD 3213;Silodosin;(R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]indoline-7-carboxamide;KAD 3213;Urief;Rapaflo;Rapallo;(R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethy l]amino]propyl]indoline-7-carboxamide;1-(3-Hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,3-dihydroindole-7-carboxamide;Urorec;Silodyx
CAS No.:160970-54-7
Molecular Formula:C25H32F3N3O4
InChIKeys:InChIKey=PNCPYILNMDWPEY-QGZVFWFLSA-N
Molecular Weight:495.53
Exact Mass:495.53
EC Number:1308068-626-2
UNII:CUZ39LUY82
DSSTox ID:DTXSID40167045
NCI Thesaurus Code:C81372
ATC Code:G04CA04|G - Genito urinary system and sex hormones
HScode:29339900
Categories:
Characteristics-
PSA:
97
XLogP3:3.6
Appearance:White to off-white solid
Density:1.249±0.06 g/cm3(Predicted)
Melting Point:105
Boiling Point:601.4±55.0 °C(Predicted)
Flash Point:317.5±31.5 °C
Refractive Index:1.552
Water Solubility:H2O: Very slightly soluble
Vapor Pressure:2.58E-15mmHg at 25°C
Specific rotation:D25 -14.0° (c = 1.01 in methanol)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H413 May cause long lasting harmful effects to aquatic life
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Imatinib mesylate
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Location:
No.21,HuanCheng West Road ,AnQing City ,Anhui Province,China
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Payment Terms:
D/P,L/C,D/A
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2009
Company Certificates-
business license
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ISO9001
ANHUI HAIKANG PHARMACEUTICAL CO.,LTD. was established in 2009 in Anqing City, Anhui Province. It is located along the north bank of mid and lower reaches of the Yangtze River. Enjoying favorable geographic superiorities and convenient transportation infrastructure: such as highway, high speed railway, airport, inland shipping container terminal and so on. By plane, it takes just 1 hour to Shanghai, 2 hours to Guangzhou or Beijing; by high speed train it takes 2 hours to reach Nanjing, 4 hours to Shanghai, 6.5 hours Beijing.Since founded the company has been committed to the production, sales and export of chemical raw materials of pharmaceutical APIs and intermediates, while as well as other services of product customization, process improvement, achievement transfer,etc.
The company covers an area of 28000 square meters. We invested 80 million Yuan to set up 3 synthesis workshops and 3 purification workshops, whose annual output value is over hundred million Yuan, and their profits and taxes are over 20 million Yuan. All our productions are in strict accordance with GMP standard and we have established a well-equipped R & D center.
Haikang currently employs 50 people. 2 of them are of doctoral degree, 6 of master degree,1 researcher returned from overseas and all the rest employees have at least college education. We have close cooperation with Zhejiang University of Technology, University of Science and Technology of China and Anhui University of Chinese Medicine ,etc. We have an academic advisors team consisting of experts and professors who have well background of medical profession and ample experience in pharmacy developing and marketing. It is a united, hard-working, courageous, rigorous and innovative team of elites.
Through years of unremitting efforts Haikang has made remarkable achievements in the R&D and production of anti-virus, antidiabetic series APIs and intermediates. The main products are ganciclovir, valganciclovir hydrochloride, valaciclovir HCL, silodosin, repaglinide, sitagliptin, imatinib and their intermediates. We have established long and stable relationship with nearly 100 domestic and international pharmaceutical manufacturers and research institutes.
To deal with increasingly fierce competition and challenges of economic globalization, Haikang adheres to the business philosophy of “Customer is First, Technology is Leading, Quality is Everything, Honesty for Development” and insists on developing scientifically, globally and diversely. Relying on our existing advantages, we focus on the integration of various resources, and actively optimize the system of decision-making, management and service. We keep up with the pace of the newest R&D trend in and outside China; keep continuous innovation to develop high-tech, market prospective products to satisfy different needs from different customers. While pursuing economic benefits, Haikang has also committed to spare no efforts to advanced environmental management. It is always a mission and moreover a responsibility for Haikang to take care of people’s health and protect the environment.
We have confidence in our future and looking forward to having sincere, win-win and brilliant cooperation with you!
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted
India
Silodasin
10 KG Dec 19, 2023 Post an enquiry for this product
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