(+)-Camptothecin 97%
TDS 1 Inquiries
7689-03-4
Industrial Grade
97%
SHANGHAI
20kg/negotiable
2019-12-31
(+)-Camptothecin
-
Product Description
-
Seller Information
-
Inquiry History
-
Description
(S)-(+)-Camptothecin (CPT) is a cytotoxic quinoline alkaloid originated from camtotheca acuminata or Nothapodytes pittosporoides(Mappia).Camptothecin was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs.
(S)-(+)-camptothecin Product (S)-(+)-camptothecin CAS# 7689-03-4 Spec. 95%,98%,99% M.F C20H16N2O4 M.W 348.34 Standard In House Packing 10kgs/carton
Maoyuan Advantage & Support1. Single impurity: less than 0.5% generally, or <0.1% as required
2.Capacity:300kg/Month
3.Leading natural plant ingredients supplier in China with 16 years’ experience.3.ISO9001&ISO14001 certified and steady supply4.Professional R&D team and strong R&D strength.
Packing & StoragePacking with IATA required carton with 10kg/carton, or as customer required.Stored in a cool, dry and dark place, shelf life 24 months.Function:Camptothecin showed remarkable anticancer activity in preliminary clinical trials by inhibiting the DNA enzyme topoisomerase I (topo I). (S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.Application:1. Camptothecin is the natural starting material of Irinotecan HCl.2. Camptothecin is the natural starting compound of 10-Hydroxycamptothecin.3. Camptothecin is the natural starting ingredient of 7-Ethyl-10-Hydroxycamptothecin(SN-38).4. Camptothecin is the natural starting ingredient of Topotecan HCl5. This compound camptothecin is a featured product for Apoptosis research.Natural origins of camptothecin1. Camptotheca acuminata (Camptotheca, Happy tree), a tree native to Hunan ,Guangxi, Sichuan province of China. Camptotheca acuminata used as a cancer treatment in Traditional Chinese Medicine.Generally, the leaves and the fruits of happy tree are applied for the extraction of camptothecin.2. Nothapodytes pittosporoides(Mappia), a tree wild spread in Hunan ,Guangxi, Sichuan province of China. The root of the tree is applied for the extraction of campothecin, most of this origin is applied for R&D.CertificatesBasic Info-
Product Name:
(+)-Camptothecin
Other Name:1,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE;(20S)-CAMPTOTHECIN;CaMpetothecin;(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin(NATURAL);CaMpathecin;4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE
CAS No.:7689-03-4
Molecular Formula:C20H16N2O4
InChIKeys:VSJKWCGYPAHWDS-FQEVSTJZSA-N
Molecular Weight:348.35
Exact Mass:348.35
BRN:631069
EC Number:444-280-6
UNII:XT3Z54Z28A
NSC Number:94600
DSSTox ID:DTXSID0030956
NCI Thesaurus Code:C338
Color/Form:yellow
HScode:29399990
Categories:
Characteristics-
PSA:
79.7
Physical Properties:Appearance: pale yellow needlelike crystal. Solubility: slightly soluble in ethanol and chloroform; poorly soluble in water; camptothecin fails to generate stable salt with acid, whereas it can produce sodium salt which is soluble in water by reacting with heated sodium hydroxide solution. Melting point: 264–267°C. Camptothecin derivatives
XLogP3:1
Appearance:yellow solid
Density:1.3112 (rough estimate)
Melting Point:260 °C (dec.)(lit.)
Boiling Point:482.73°C (rough estimate)
Flash Point:411.6±32.9 °C
Refractive Index:1.5700 (estimate)
Water Solubility:insoluble
Storage Conditions:2-8°C
Toxicity:Oral-rat LD50: 153 mg/kg; Oral-Mouse LD50: 50.1 mg/kg
Flammability characteristics:Thermal decomposition emits toxic nitrogen oxide fumes; reacts with acids to decompose
Specific rotation:D25 +31.3° (in chloroform-methanol, 8:2)
PKA:pKa 10.83 (Uncertain)
Collision Cross Section:181.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
(+)-Camptothecin
-
Payment Terms:
D/P,L/C
-
Average lead Time:
60
-
Total Annual Revenue:
Less than $1 million
Pengzhou Maoyuan Biological Technology Co., Ltd. was established in 2000. It is a company specializing in the production of camptothecin. It has sophisticated technical equipment and a high-quality workforce. Our company mainly produces camptothecin, andrographolide, andrographis paniculata extract, monthly production of camptothecin 25kg, purity is divided into 95%, 98%, 99% three grades (can also be processed according to customer needs of different purity camptothecin ); Andrographolide monthly production 600Kg, content 98% (high performance liquid chromatography); Andrographis paniculata extract monthly production 1200Kg, dehydrated andrographolide content greater than 5%. Relevant testing data is provided by the well-known domestic testing organization-West China Medical University. "Quality, integrity-based" is our consistent aim. We sincerely welcome pharmaceutical production companies, scientific research units, and institutions to purchase our products. We will continue to strengthen cooperation with domestic pharmacy colleges and always maintain a high standard of product quality.
-
-
Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
(S)-(+)-Camptothecin
1000 KG Nov 7, 2024 Post an enquiry for this product
