Mitomycin C 99%
50-07-7
USP / EP / BP / JP Grade
99%
SHANGHAI
1kg/Customer requirements
2019-12-29
chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceIt is a crystalline powder or a powder with blue-purple shiny crystal. Its solid state is stable, while easily deactivated in acidic and alkaline solution. Mp> 360 ℃; the maximum absorption wavelength in methanol is 216nm, 360nm and 560nm.The maximum absorption wavelength in aqueous solution is 365nm ± 2nm. This product is soluble in water, methanol, acetone and ethyl acetate and other organic solvents, slightly soluble in benzene, ether and carbon tetrachloride, insoluble in petroleum ether. H
Mitomycin c appears as blue-violet crystals. Used as an anti-tumor antibiotic complex. (EPA, 1998)|Solid
Mitomycin c appears as blue-violet crystals. Used as an anti-tumor antibiotic complex. (EPA, 1998)|Mitomycin C is a mitomycin. It has a role as an antineoplastic agent and an alkylating agent.|Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus. It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discovered that work via this alkylating mechanism, making mitomycin relatively unique in the space of microbiota-derived therapies. Mitomycin's cross-linking activity has resulted in its approval for the treatment of a variety of cancers - the most recent of which is an April 2020 approval for its use in low-grade Upper Tract Urothelial Cancer (LG-UTUC) - as well as adjunctly to ab externo glaucoma surgeries.|Mitomycin is an Alkylating Drug. The mechanism of action of mitomycin is as an Alkylating Activity.|Mitomycin is a cytotoxic antibiotic which is used as anticancer therapy of advanced cancers of the stomach and pancreas. Mitomycin in combination with other anticancer agents frequently causes mild-to-moderate serum enzyme elevations during therapy and is capable of causing sinusoidal obstruction syndrome, but mitomycin by itself has not been specifically linked to instances of clinically apparent liver injury with jaundice.|Mitomycin is a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)|An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.Basic Info-
Product Name:
Mitomycin C
Other Name:Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-,(1aS,8S,8aR,8bS)-;Mitomycin C;Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-5-methyl-,carbamate (ester);Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-,[1aS-(1aα,8β,8aα,8bα)]-;(1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione;Ametycine;NSC 26980;Mitomycin;MitoExtra;Mitonco;Mitoplus;MMC;Mitocin C;Mutamycin;Mytomycin Kyowa S;Mitozytrex;7481-68-7;74349-48-7;144085-53-0
CAS No.:50-07-7
Molecular Formula:C15H18N4O5
InChIKeys:InChIKey=NWIBSHFKIJFRCO-WUDYKRTCSA-N
Molecular Weight:334.33
Exact Mass:334.33
EC Number:200-008-6
UNII:50SG953SK6
NSC Number:26980
UN Number:2811|3077
DSSTox ID:DTXSID2020898
NCI Thesaurus Code:C1820
Color/Form:BLUE-VIOLET CRYSTALS
ATC Code:L - Antineoplastic and immunomodulating agents
HScode:29419090
Categories:
Characteristics-
PSA:
147
XLogP3:-0.4
Appearance:blue-gray powder
Density:1.2238 (rough estimate)
Melting Point:>360 °C
Boiling Point:534 °C
Flash Point:305.6ºC
Refractive Index:1.68
Water Solubility:H2O: 4 mL/vial Stock solutions should be filter sterilized and stored at 2-8 °C in the dark., clear to slightly hazy, blue to purple
Storage Conditions:2-8°C
Toxicity:Oral-rat LD50: 30 mg/kg; Oral-Mouse LD50: 23 mg/kg
Flammability characteristics:Flammable; burning produces toxic nitrogen oxide fumes
PKA:10.9None
Henrys Law Constant:LogP = -0.38; Henry's Law constant = 2.5X10-10 atm-cu m/mol
Dissociation Constants:10.9
Collision Cross Section:169.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Air and Water Reactions:Water soluble.
Reactive Group:Amides and Imides
Reactivity Profile:MITOMYCIN C is sensitive to prolonged exposure to light. It may be sensitive to prolonged exposure to air. This chemical is incompatible with strong oxidizing agents, strong acids and strong bases. Calcium salts may cause decomposition. (NTP, 1992)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Carcinogenicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H351 Suspected of causing cancer
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Mitomycin powder for injection should be protected from light and preferably stored at 15-30 deg C: temperature greater than 40 deg C should be avoided.
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Seller Information
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Business Type:
Manufactory
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Main Products:
chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC
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Location:
No 7 ,Huacai International Building,Dengcai Road,Sandun,Westlake District,Hangzhou,Zhejiang
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Payment Terms:
L/C,100% TT in advance
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Average lead Time:
30
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
101-200
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Year of Establishment:
2011
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Certifications:
ISO,FDA,CE
Gihi Chemicals: is specialized in the production of ester products which are used in the daily dietary supplements chemicals ,cosmetic products and skincare products since 1999.
Since 2010，GIHI CHEMICALS , begun to focus on the development and production of high-quality healthy Dietary supplements for our global high-reputation customers. The purity of all healthy Dietary supplements we provide has reached more than 99% purity. From the beginning of our products’ development, our technical engineers have chosen and design the production routes to ensure that we have been able to use biological, enzyme and water-phase green synthesis methods during the large production process to ensure that our health dietary supplements is truly high-quality ,green &environmental friendly, which are truly good and health to the human body.
Now our company has:
1 sales & management center + 3 research centers+ 4 production factories.
with ISO9001 & FDA certificate & CE certificate, accordance with GMP requirements.
1 Sales &Management center:
Add:No.567 Dengcai Street, Sandun, Westlake District, Hangzhou 310030, Zhejiang, China.
Research Center 1: (Chemical synthesis lab)
No.6, Chanyexietongchuanxing Center, Kangyang Road, Shangyu Economic and Technological Development Zone, Shaoxing, Zhejiang，China.
This research center: is specialized in chemical synthesis, our this research center could synthesis more than 300 new chemical products for many china pharmaceutical companies every year.
Research Center 2:(For Enzyme biology technical and Enzyme catalyst technical)
No.7, Lixiangxi Road, changsha Economic and Technological Development Zone, Changsha, Hunan.
Our this research center is committed to the applications of immobilized enzymes technology to the development of products such as peptides, polysaccharides, and non-natural amino acids. The products developed are widely used in medicine, health products, cosmetics, food, feed and other industries. The company adopts multidisciplinary technologies of chemistry, materials science and life sciences, which helps to meet the demand of green production while improving product quality and economic benefits. And also helps to reduces the emission of "three industrial pollution" greatly.
Research Center 3:(Biology enzyme-catalytic products)
No.2 Bio-hatch Building,No.10 Gaoxinzhongyidao, Yuehai Street,Nanshan District, Shenzhen, Guangdong, China.
This research center is specialized in biosynthesis technology as the core technology, and multi-disciplinary cross-application as target. We are the first batch company in the world to apply enzyme catalysis technology to the large-scale production of peptides, carbohydrates and nucleic acids and other special functional raw materials, and actively explore products in new application in the field. In this center, we used enzyme catalyst production methods to produce many high lever products, such as: NMN, (S)-Prox-ylane, Ectoin, Ergothioneine,etc.
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