Neratinib Pharmacy Grade
1 Inquiries
698387-09-6
Pharmaceutical Grade
99%
SHANGHAI
25kg/Cardboard Drum
2019-07-07
Anti-tumor categories,Cardiovascular,Anti-Diabetes Class,4-(4-bromo-2-fluoroanilino)-6-methoxy-1H-quinazolin-7-one,4-Amino-3-chlorophenol hydrochloride,4-Amino-3-chlorophenol
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceChEBI: A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an ethoxy group at the 7-position.
Neratinib is a quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enoylamido group at the 6-position, and an ethoxy group at the 7-position. It has a role as a tyrosine kinase inhibitor and an antineoplastic agent. It is a member of quinolines and a nitrile.|Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer.|Neratinib is a Kinase Inhibitor. The mechanism of action of neratinib is as a Kinase Inhibitor, and P-Glycoprotein Inhibitor.|Neratinib is an orally available tyrosine kinase receptor inhibitor that is used in the extended adjuvant therapy of early stage breast cancer. Neratinib is associated with a low rate of transient elevations in serum aminotransferase levels during therapy, but has not been convincingly linked to cases of clinically apparent liver injury with jaundice.|Neratinib is an orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.Basic Info-
Product Name:
Neratinib
Other Name:2-Butenamide,N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-,(2E)-;(2E)-N-[4-[[3-Chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;HKI 272;(E)-N-[4-[3-Chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide;Neratinib;(E)-N-[4-[[3-Chloro-4-((pyridin-2-yl)methoxy)phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)-2-butenamide;736156-77-7
CAS No.:698387-09-6
Molecular Formula:C30H29ClN6O3
InChIKeys:InChIKey=JWNPDZNEKVCWMY-VQHVLOKHSA-N
Molecular Weight:557.04266
Exact Mass:557.04
EC Number:1308068-626-2
UNII:JJH94R3PWB
DSSTox ID:DTXSID70220132
NCI Thesaurus Code:C49094
ATC Code:L01EH02|L - Antineoplastic and immunomodulating agents
HScode:29334900
Categories:
Characteristics-
PSA:
112
XLogP3:4.9
Density:1.33
Boiling Point:757°C at 760 mmHg
Flash Point:411.601ºC
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Anti-tumor categories,Cardiovascular,Anti-Diabetes Class,4-(4-bromo-2-fluoroanilino)-6-methoxy-1H-quinazolin-7-one,4-Amino-3-chlorophenol hydrochloride,4-Amino-3-chlorophenol
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Location:
No.9 Weidi Road-Jiangsu Life Science and Technology Innovation Park, Nanjing, P.R.C
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Payment Terms:
TT against copy of documents
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Average lead Time:
7
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2008
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Certifications:
business license
Nanjing CHICO Pharmaceutical Co., Ltd is a high-tech enterprise specializing in R&D, production and sales of APIs and pharmaceutical intermediates. We are recognized as National High-Tech Enterprises by Science and Technology Department of Jiangsu Province in 2014.Adhering to the "Consummate service Convincing honor" business strategy, CHICO will provide you the qualified products and first-class service which are based on our strong technical accumulation and outstanding professionalism.
CHICO was established in July 2008, our sales office and R&D center is located in No.9 Weidi Road -Jiangsu life science and Technology Innovation Park, covering an area of about 1800 square meters. Our GMP factory is located in AnQing--- AnQing CHICO pharmaceutical Co., LTD, with a total area of 20000 square meters. Meanwhile, we also have set our cooperative production base in Huai’an. Now we have a complete ,stable production chain of gram-kilogram-ton so that we can achieve rapid response in the whole R&D-scale up- producing process for new products at the first time.
We always regard the quality as life, thus we have established our quality department which is directly controlled by GM. Also we have set a perfect quality assurance system and strict quality control standards according to the GMP requirements' and we have already passed the ISO 9001 quality system certification.
We warmly thank the new and old customers that support and cooperate with us. We sincerely look forward to using "integrity, quality, efficient, professional" service to enhance mutual friendship and create brilliance hand in hand with you!
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
India
Neratinib 99%
10 G Nov 14, 2023 Post an enquiry for this product
