Osimertinib Mesylate (AZD9291)
1421373-66-1
Pharmaceutical Grade
SHANGHAI
1kg/Plastic Bag
2021-08-31
Cisplatin,Sorafenib tosylate,Tauroursodeoxycholic acid,Gefitinib,Netupitant,Sodium glycochenodeoxycholate
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Product Details
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Seller Information
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Description
Osimertinib mesylate (CAS No.: 1421373-66-1) is supplied by SZ BICHAL BIOLOGICAL TECHNOLOGY CO.,LTD, a Manufactory with 7 years on ECHEMI.
Key details: grade Pharmaceutical Grade, packaging 1kg/Plastic Bag, port SHANGHAI.
Contact the supplier on this page to request a quotation or the latest price.
ECHEMI Editorial ReferenceOsimertinib is active against exon 19 deletions, exon 21 mutations, and also the exon 20 T790M mutations. It is preferentially selective for mutated EGFR, and therefore toxicity at therapeutic doses is lower than for first- and second-generation agents. Notably, osimertinib is able to cross the blood-brain barrier, making it active against disease in the CNS.
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. Used for treatment of EGFR T790M mutation positive non-small cell lung cancer.
Class: receptor tyrosine kinaseTreatment: NSCLCOral bioavailability = 70%Elimination half-life = 48 hProtein binding = 94.7%Basic Info-
Product Name:
Osimertinib mesylate
Other Name:AZD-9291 (Mesylate);N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);AZD-9291 mesylate N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide methanesulfonate (1:1);Osimertinib;N-[2-(2-dimethylaminoethylmethylamino)-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide mesylate salt;Osimertinib Mesylate(AZD9291);Osimertinib mesylate;Mereletinib mesylate
CAS No.:1421373-66-1
Molecular Formula:C29H37N7O5S
InChIKeys:FUKSNUHSJBTCFJ-UHFFFAOYSA-N
Molecular Weight:595.72
EC Number:200-064-1
Color/Form:Off-White to Yellow
HScode:29339900
Characteristics-
Melting Point:
>232°C (dec.)
Critical Temperature & Pressure:-20°C Freezer, Under inert atmosphere
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Sub-category 1B
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 1
Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H317 May cause an allergic skin reaction
H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
H400 Very toxic to aquatic life
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Cisplatin,Sorafenib tosylate,Tauroursodeoxycholic acid,Gefitinib,Netupitant,Sodium glycochenodeoxycholate
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Location:
No32 Huoju Road , New& High Industry Park, Suzhou , China.
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
7 days
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
11-50
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Year of Establishment:
2010
SU ZHOU BICHAL BIOLOGICAL TECHNOLOGY CO., LTD is a fast-growing pharmaceutical company that engages in the research, development, manufacture and market of active pharmaceutical Ingredient (API) and its intermediates with outsourcing services for pharmaceutical research.
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