Tris is a white crystalline powder with good water solubility. It is soluble in ethanol, ethyl acetate, benzene and water, insoluble in ether and carbon tetrachloride, and has corrosive effect on copper and aluminum. When it is used as biological buffer and reference material for ACIDOMETRIC titration, the purity requirement is high. However, at present, the preparation of standard level trimethylaminomethane is not perfect. The commonly used method is to dissolve industrial grade trimethylamine methane in distilled water and recrystallize it for many times to prepare reference grade trimethylamine methane. This method has the disadvantages of complex process, small output, poor uniformity and high cost in the production of kilogram batch products, and the material discoloration or decomposition caused by too high temperature in the concentration process leads to the reduction of product qualification rate.
The synthesis process of trimethylol aminomethane is as follows
1. Preparation method of trihydroxymethyl aminomethane: adding trihydroxymethyl methane into methanol aqueous solution, heating to 50-70 ℃, stirring and dissolving, wherein the mass volume ratio of trihydroxymethyl methane to methanol aqueous solution is 8:3-7 according to g / ml, the methanol aqueous solution is prepared by mixing pure water and methanol according to the volume ratio of 2:3; adding charcoal activated carbon to the solution, wherein The weight ratio of charcoal activated carbon and trimethylolmethane is 0.5-2:100, keep temperature at 45-55 ℃ for 20-40 minutes, and then filter while hot to collect the filtrate. The filtrate is concentrated under reduced pressure at 70-80 ℃ until crystallization occurs, and then put it in a cool place. After the crystallization is separated by suction filtration, the filtrate is washed with anhydrous ethanol and dried at 40-60 ℃ for 3-5 hours.
2. The synthesis method of trimethylol aminomethane: it uses nitromethane and excessive paraformaldehyde as the main raw materials, condenses at a certain temperature to form trimethylol nitromethane; then under a certain temperature, pressure, solvent and catalyst, through hydrogenation reduction reaction, through crystallization, recrystallization to produce trimethylol aminomethane.
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