157716-52-4
157716-52-4
98%
上海
1g,5g,10g,25g,100g,1kg/Cardboard Drum
2021-03-31
2-phenyl-1,4-oxadiazole,8-fluorochroman-4-amine,7-diazaspiro[4.5]decane-2-carboxylate,7-dibromochroman-4-amine,tert-butyl 2
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferencePerifosine is an oral Akt inhibitor. All cells are sensitive to the antiproliferative properties of Perifosine with an IC50 of ~0.6-8.9 μM.
Perifosine is a phospholipid consisting of 1,1-dimethylpiperidinium-4-yl hydrogen phosphate in which the hydrogen is replaced by a stearyl (octadecyl) group. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor. It is a phospholipid and an ammonium betaine. It derives from an octadecan-1-ol.|Perifosine is a novel alkylphospholipid with antiproliferative properties attributed to protein kinase B inhibition.|Perifosine is an orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. Perifosine has a lower gastrointestinal toxicity profile than the related agent miltefosine. (NCI04)Basic Info-
Product Name:
Perifosine
Other Name:Piperidinium,4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-,inner salt;D 21266;Perifosine;NSC 639966;KRX 0401;(1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
CAS No.:157716-52-4
Molecular Formula:C25H52NO4P
InChIKeys:InChIKey=SZFPYBIJACMNJV-UHFFFAOYSA-N
Molecular Weight:461.663
Exact Mass:461.363403
EC Number:1592732-453-0
UNII:2GWV496552
NSC Number:639966
DSSTox ID:DTXSID3048946
NCI Thesaurus Code:C1727
HScode:2933399090
Categories:
Characteristics-
PSA:
58.6
XLogP3:8.3
Appearance:white to beige
Melting Point:271-272° (dec)
Water Solubility:H2O: soluble10mg/mL, clear
Storage Conditions:-20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Eye irritation, Category 2
Reproductive toxicity, Category 1B
Reproductive toxicity, Additional category for effects on or via lactation
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
H362 May cause harm to breast-fed children
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
2-phenyl-1,4-oxadiazole,8-fluorochroman-4-amine,7-diazaspiro[4.5]decane-2-carboxylate,7-dibromochroman-4-amine,tert-butyl 2
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Location:
No. 165, Zhongshe Road, Maogang Town, Songjiang District, Shanghai
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Payment Terms:
TT against copy of documents
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Average lead Time:
5 days
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Total Annual Revenue:
Less than $1 million
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Total Employees:
51-100
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Year of Establishment:
2008
Company Certificates-
Certificate 1
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