Perifosine
157716-52-4
99%
2026-07-01
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Perifosine Cat No CEI-0114 Description Perifosine can inhibit Akt with IC50 og 4.7 uM. Alias KRX-0401 CAS No 157716-52-4 Molecular Weight 461.66 Purity >99% Storage 2 years at -20centigrade Powder Synonyms KRX-0401 Targets Akt Molecular Formula C25H52NO4P Chemical Name Piperidinium, 4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-, inner salt Solubility DMSO In vitro Perifosine (D-21266, KRX-0401) is an analogue of miltefosine. Perifosine, a bioavailable ALK (Alkylphospholipids)showed antiproliferative properties on the cell cycle kinetics of immortalized keratinocytes (HaCaT) as well as head and neck squamous carcinoma cells with an IC50 of 0.6-8.9 uM. Perifosine induced both G(1)-S and G(2)-M cell cycle arrest at the concentration of 20 uM, together with p21(WAF1) expression in both p53 wild-type and p53(-/-) clones.Perifosine blocks cell cycle progression of head and neck squamous carcinoma cells at G(1)-S and G(2)-M by inducing p21(WAF1), irrespective of p53 function. Perifosine causes dose-dependent inhibition of protein kinase B/Akt phosphorylation and thus activation at concentrations causing growth inhibition of PC-3 prostate carcinoma cells. perifosine decreases the plasma membrane localization of Akt, and this is substantially relieved by MYR-Akt along with relief of downstream drug effect on induction of p21(WAF1/CIP1). Perifosine does not directly affect phosphoinositide 3-kinase (PI3K), phosphoinositide-dependent kinase 1, or Akt activity at concentrations inhibiting Akt phosphorylation and membrane localization. category Inhibitors(c1514) cas_num 157716-52-4 Basic Info-
Product Name:
Perifosine
Other Name:Piperidinium,4-[[hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethyl-,inner salt;D 21266;Perifosine;NSC 639966;KRX 0401;(1,1-Dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
CAS No.:157716-52-4
Molecular Formula:C25H52NO4P
InChIKeys:InChIKey=SZFPYBIJACMNJV-UHFFFAOYSA-N
Molecular Weight:461.663
Exact Mass:461.363403
EC Number:1592732-453-0
UNII:2GWV496552
NSC Number:639966
DSSTox ID:DTXSID3048946
NCI Thesaurus Code:C1727
HScode:2933399090
Categories:
Characteristics-
PSA:
58.6
XLogP3:8.3
Appearance:white to beige
Melting Point:271-272° (dec)
Water Solubility:H2O: soluble10mg/mL, clear
Storage Conditions:-20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Eye irritation, Category 2
Reproductive toxicity, Category 1B
Reproductive toxicity, Additional category for effects on or via lactation
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H319 Causes serious eye irritation
H360 May damage fertility or the unborn child
H362 May cause harm to breast-fed children
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P203 Obtain, read and follow all safety instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P263 Avoid contact during pregnancy and while nursing.
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product