Genistein 98% Off-white dendritic needle crystal powder.

Genistein, mainly exists in legumes, such as sophora pseudoacacia horn, mountain bean root content is larger.

Genitin, also known as genitin, is a rectangular or hexagonal rod crystal (60% ethanol), dendritic crystal (ether), melting point 297-298℃ (slightly decomposed). It is soluble in DMSO and ethanol, and almost insoluble in water, with a solubility of 8.7 μ g/ml in water. Changing the pH of the solution has no significant effect on genitin.

Chinese name

genistein

Foreign names

Genistein

Molecular formula

C15H10O5

The molecular weight

270.24

Don't name

Genistein

Melting point

297-298 ℃

The basic information

4',5, 7-trihydroxyisoflavone; 5,7,4 '- TRIHYDROXYISOFLAVONE; 5, 7 - DIHYDROXY - 3 - (4 - HYDROXYPHENYL) - 4 h - 1 - BENZOPYRAN - 4 - ONE; 5, 7 - DIHYDROXY - 3 - (4 - HYDROXY - PHENYL) - CHROMEN - 4 - ONE; AKOS NCG1-0029; 4 ', 5, 7 - trihydroxy - isoflavon; 5, 7 dihydroxy - 3 - (4 - hydroxyphenyl) - 4 h - 1 - benzopyran - 4 - on; c.i.75610; differenola; genistein(synthetic); genisteol; genisterin; prunetol; sophoricol; 5, 7 dihydroxy - 3 - (4 - hydroxyphenyl) - 4 - benzopyrone; Natural Genistein; GENISTEIN FROM GLYCINE MAX (SOYBEAN); GENISTEIN FROM SOYBEAN 98%(HPLC); Genistein98%,99%

【 英 文 名 称 】 4',5, 7-trihydroxyisoflavone; Goldenrod isoflavone; Genistein; 4 ',5, 7-trihydroxy isoflavones; 5, 7-dihydroxy-3 -(4-hydroxyphenyl) -4H-1-benzopyran-4-one; Genistein; Genistein; Trihydroxyisoflavone; Natural dyestuff lignin; Genistein; Genistein/trihydroxyisoflavone/genistein; Isooflavin; Dyewood yellow; Genistein,4',5,7 trihydroxy isoflavone; Genistein; Dye lignin; 4',5, 7-trihydroxyl isoflavones,97%

5, 7-dihydroxy-3 -(4-hydroxyphenyl) -4H-1-benzopyran-4-one; 4',5, 7-trihydroxyl isoflavones

【C A S 号】 446-72-0

[Origin] It is the root of leguminous plant Genista Tinctoria Linn., Sophora subprostrala Chun et T.Chen.

broom

broom

98%

[Physical properties] Off-white dendritic needle crystal powder. Mp297 ℃ to 298 ℃. Soluble in common organic solvents, almost insoluble in water, soluble in dilute alkali.

Pharmacological effect

(1) it has estrogen and anti-estrogen properties.

(two) with antioxidant effect.

It can inhibit the activity of tyrosine protein kinase (PTK)

(4) It can inhibit the activity of topological isomerase ⅱ.

(5) It has the effects of inducing programmed cell death, improving anticancer efficacy and inhibiting angiogenesis, etc. It is a potential cancer chemoprevention agent, and its anticancer effect and mechanism have a wide application prospect.

【 Source 】 It mainly exists in legumes, such as sophora pseudoacacia and sophora root.

standard

Product name: genistein

English name: Genistein

CAS NO: 446-72-0

5,7,4 '-trihydroxyisoflavone genistein isoflavone

Sub type: C15H10O5 sub quantity: 270.23 Specification content: 98%

Detection method: HPLC Product shape: light yellow powder crystal

Physical properties: Melting point 297℃-298℃, soluble in DMSO and ethanol, almost insoluble in water.

Light yellow crystalline powder; Soluble in common organic solvents, soluble in dilute alkali yellow.

Pharmacological effects: it has antioxidant, estrogenic and anti-estrogenic properties, and can inhibit the activity of expandable foreign body enzyme II and the activity of tyrosine protein kinase PTK.

Product Source: Leguminous plant Genista Tinctoria Linn rhizome

Production process: mainly by alcohol extraction, extraction, crystallization and other processes to complete

Storage: cool and dry, avoid light and high temperature

Warranty period: 2 years (tentative)

Product use

Used for anti-tumor, bacteriostatic, hypolipidemic, estrogen-like effect.

Antitumor effect

Inhibition of cell cycle: stop cells with G2/M phase; Induction of tumor cell apoptosis: up-regulation of the relevant pro-apoptotic genes, down-regulation of the corresponding anti-apoptotic genes, to promote the apoptosis of tumor cells to prevent and limit the occurrence of tumor;

bacteriostatic

Its antibacterial mechanism is realized by destroying the integrity of cell wall and cell membrane, inhibiting TCA circulation pathway and protein synthesis. This is consistent with Kim's view on the antibacterial mechanism of drugs [11]. Since genistein has physiological activities such as bacteriostasis and antioxidant activity, from the perspective of nutrition, if Gen is selected as a food additive, it can play its dual role and has a very broad application prospect. [2]

Estrogen-like effect

GEN (genistein or genistein) and its aglycone are the most abundant components in soybean isoflavones. The aglycone form of soybean isoflavones has higher activity than the glycoside form, especially the higher GEN activity, which has bidirectional regulation of phytoestrogens. McF-7 cells are ER positive human breast cancer cell lines, which can be specifically regulated by estrogen or estrogen-like active substances to proliferate. Estrogen-like increase is very sensitive, simple, and can distinguish between agonists and antagonists, so it is widely used in rapid screening and evaluation of environmental estrogens.

It has been reported that GEN can be used as estrogen to penetrate rustic gene expression, suggesting that GEN binding with estrogen receptor can not only produce anti-estrogen-like effect, but also show certain estrogen effect by activating estrogen response elements