 Home > Pharmaceutical Intermediates > Antineoplastics > 7-Ethyl-10-hydroxycamptothecin for Sale > SN-38 (7-Ethyl-10-hydroxycamptothecin ) 98% yellow crystalline powder Xieli

SN-38 (7-Ethyl-10-hydroxycamptothecin ) 98% yellow crystalline powder Xieli

Name: SN-38 (7-Ethyl-10-hydroxycamptothecin ) 98% yellow crystalline powder Xieli
Brand: Xieli
SKU: pr2202283222
Price: 25 USD
Availability: InStock

2 Inquiries

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CAS No.:

86639-52-3

Grade:

Pharmaceutical Grade

Content:

98%

Brand:

Xieli

Packaging:

according to customer requirement

Sample Available:

Yes

Price valid (until):

2023-04-01

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sichuan xieli pharmaceutical co., ltd

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

15 days

Qualification:

Main Products:

dasatinib,ingenol mebutate,hesperidin,irinotecan HCL,erlotinib,nastrozole

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Product Description
Seller Information
Inquiry History

Description

Items	Specifications
Appearance	Yellow crystalline powder
CAS	86639-52-3
Molecular Formula	C22H20N2O5
Melting Point	217 °C

Introduction of SN-38

SN-38 is a bioactive metabolite of irinotecan hydrochloride (CPT-11). SN-38 caused the strongest inhibition of DNA topoisomerase I, followed by CPT, and then CPT-11. CPT-11 dose dependently transferred the position of loose DNA in the direction of incision DNA, but SN-38 and CPT had no effect on the position of loose DNA. SN-38 inhibited DNA synthesis in a dose-dependent and time-dependent manner. The respective IC50 value of SN-38 is 0.077 μ m in DNA synthesis. The inhibitory effect of SN-38 on cellular RNA synthesis is less than that on DNA synthesis and it does not inhibit protein synthesis. SN-38 caused frequent DNA single strand breaks in P388 cells.

About us

Xieli Pharm was Founded in 1980's as professional manufacturer on oncology& Animal/botanical derivative APIs and CMO services, with cGMP\ EU GMP\ Japan GMP certified factory and independent R& D center. R& D team with rich experience in process development in R& D, process scale-up and production, and succeed to finish many CMO projects. RA team with rich experience for global registration. DMF including 17 products registered in 100+ countries and submission 500+ times. Irinotecan certificated with Japan GMP and EU GMP. Rutin and Troxerutin certificated with EU-GMP; CEP for Diosmin & Troxerutin& Irinotecan HCl& Gefitinib& Anastrozole. OEM for plant extracting and TCM Processing. CDMO for Process Development, Intermidate, APIs, Formulation and Clinic Study.

ECHEMI Editorial Reference

SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively.
SN-38 is a member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself. It has a role as an apoptosis inducer, an EC 5.99.1.2 (DNA topoisomerase) inhibitor, a drug metabolite and an antineoplastic agent. It is a pyranoindolizinoquinoline, a delta-lactone, a tertiary alcohol and a member of phenols.|7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan [DB00762], a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.|A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.

Basic Info

Product Name:

7-Ethyl-10-hydroxycamptothecin

Other Name:

1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4,9-dihydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,4,11-diethyl-4,9-dihydroxy-,(S)-;(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;7-Ethyl-10-hydroxycamptothecin;SN 38 (pharmaceutical);SN 38;10-Hydroxy-7-ethylcamptothecin;7-Ethyl-10-hydroxy-20(S)-camptothecin;SN 38 lactone;(S)-SN 38;(19S)-10,19-Diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;113015-38-6

CAS No.:

86639-52-3

Molecular Formula:

C22H20N2O5

InChIKeys:

InChIKey=FJHBVJOVLFPMQE-QFIPXVFZSA-N

Molecular Weight:

392.4

Exact Mass:

392.40

EC Number:

1592732-453-0

UNII:

0H43101T0J

NSC Number:

673596

DSSTox ID:

DTXSID4040399

HScode:

2942000000

Categories:

Antineoplastics

Characteristics

PSA:

100

XLogP3:

1.4

Appearance:

light-yellow solid

Density:

1.5±0.1 g/cm3

Melting Point:

217 °C

Boiling Point:

810.3°C at 760 mmHg

Flash Point:

443.8±34.3 °C

Refractive Index:

1.738

Water Solubility:

DMSO: soluble 1mg/mL

Storage Conditions:

−20°C

See More 7-Ethyl-10-hydroxycamptothecin Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 7-Ethyl-10-hydroxycamptothecin Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
dasatinib,ingenol mebutate,hesperidin,irinotecan HCL,erlotinib,nastrozole

Location:
NO.588, middle section of mudan avenue

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
15 days

Total Annual Revenue:
Above $100 million

Total Employees:
501-1000

Year of Establishment:
1992

Company Profile
Xieli Pharm was founded in 1980's with cGMP\ EU GMP\ Japan GMP certified factory and independent R&D center. Irinotecan certificated with Japan GMP and EU GMP. Rutin and Troxerutin certificated with EU-GMP; CEP for Diosmin and Troxerutin OEM for plant extracting and TCM Processing CDMO for Process Development, Intermidate, APIs, Formulation and Clinic Study.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	7-Ethyl-10-Hydroxy CamptothecinTotal Synthesis Manufacturer(CAS No.130194-92-2 86639-52-3 119577-28-5)	5 KG	Jun 13, 2026
India	7 Ethyal 10 Hydroxycaptothecin	100 KG	May 23, 2024

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SN-38 (7-Ethyl-10-hydroxycamptothecin ) 98% yellow crystalline powder Xieli

Product Description

Seller Information