1,2-Dichloroethane

1,2-Dichloroethane

1,2-Bichloroethane;1,2-DCE;1,2-Dichloorethaan;1,2-Dichlor-aethan;1,2-Dichlorethan;1,2-Dichlorethane;1,2-dichloro-ethan;1,2-dichloroethane (ethylene dichloride)

107-06-2

C2H4Cl2

WSLDOOZREJYCGB-UHFFFAOYSA-N

98.96

98.96

605264

203-458-1

TSCA listed

APHA: ≤10

2903 15 00

Bulk Drug Intermediates

0

Clear, colorless, oily liquid with a pleasant, chloroform-like odor. The average least detectable odor threshold concentrations in water at 60 °C and in air at 40 °C were 12 and 52 mg/L, respectively (Alexander et al., 1982). Experimentally determined detection and recognition odor threshold concentrations were 25 mg/m3(6 ppmv) and 165 mg/m3(41 ppmv), respectively (Hellman and Small, 1974).

1.46400

Ethylene dichloride appears as a clear colorless liquid with a chloroform-like odor. Flash point 56°F. Denser than water and insoluble in water. Vapors are heavier than air. Density 10.4 lb / gal.

1.256 g/mL at 25 °C (lit.)

-35 °C (lit.)

83 °C (lit.)

13ºC

n20/D1.444(lit.)

8.7 g/L (20 ºC)

0-6ºC

87 mm Hg ( 25 °C)

3.4 (20 °C, vs air)

The estimated daily intake of 1,2-dichloroethane was similar for each rat strain at each dose level. Rats administered drinking water containing 8,000 ppm 1,2-dichloroethane received an esti mated intake of about 500-725 mg/kg per day. This estimated daily intake is close to the report ed oral LDso for 1,2-dichloroethane adminis tered by gavage (680-850 mg/kg) (McCollister et al., 1956); however, intake of this dose over 24 hours rather than as a bolus resulted in little toxicity.1,2-Dichloroethane toxicity administered by gavage or in formulated drinking water was compared in F344/N rats. Gavage doses were calculated to be approximately equivalent (in milligrams per kilogram) to the range of expo sures resulting from the formulated water mix tures. The F344/N rats were more sensitive to 1,2-dichloroethane administered by gavage than in drinking water, as evidenced by the fact that all males receiving 240 and 480 mg/kg and 9/10 females receiving 300 mg/kg died before the end of the studies.Toxic encephalopathy is the most common and serious disorder resulting from DCE intoxication.

Highly flammable

vol% in air: 4.26

Chloroform-like odor

Sweet taste

11.24 at 30 °C (headspace-GC, Sanz et al., 1997)

Highly flammable. Slightly water soluble.

Liquid ammonia and 1,2-Dichloroethane can cause an explosion when mixed, NFPA 491M, 1991. A tank of dimethyl amino propyl amine exploded violently when 1,2-Dichloroethane reacted with wet 1,2-Dichloroethane which had been the tank's previous contents [Doyle 1973]. Halogenated aliphatic compounds, such as 1,2-Dichloroethane , are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, epoxides, aluminum

775 °F

0-6°C