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Pemetrexed disodium INT-6

Unit Price: Get Latest Price
CAS No.:

137281-23-3

Grade:

Pharmaceutical Grade

Content:

99%

Port:

beijing;shanghai

Brand:

shandong boyuan

Packaging:

25kg/Cardboard Drum

Price valid (until):

2024-11-30

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib

  • Product Description

  • Seller Information

  • Description

    (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioicacid;PeMetrexed-13C5;PeMetrexed-15C5;N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMicacid(PeMetrexedacid);N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1HChemicalbook-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMicacid;(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi;N-[4-[2-(2-Amino-4,7;(2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioicacid


    Pemetrexed (LY231514) is a folate antagonist. Pemetrexed (LY231514) inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide nucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM, and 65 nM, respectively.

    Items Specifications
    solubility slightly sol. in Methanol
    color White to Blue
    form powder to crystal
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    Basic Info
    Product Name:

    Pemetrexed

    Other Name:

    L-Glutamic acid,N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-;L-Glutamic acid,N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-;1H-Pyrrolo[2,3-d]pyrimidine,L-glutamic acid deriv.;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid;Pemetrexed;NSC 698037;N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid;(S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic acid

    CAS No.:

    137281-23-3

    Molecular Formula:

    C20H21N5O6

    InChIKeys:

    InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N

    Molecular Weight:

    427.41

    Exact Mass:

    427.41

    UNII:

    04Q9AIZ7NO

    NSC Number:

    698037

    DSSTox ID:

    DTXSID2048329

    NCI Thesaurus Code:

    C61614

    Color/Form:

    Crystals from 50% methanol/methylene chloride

    ATC Code:

    L01BA04|L - Antineoplastic and immunomodulating agents

    HScode:

    2933990090

    Categories:

    Antineoplastic Agents

    Characteristics
    PSA:

    187

    XLogP3:

    0.2

    Density:

    1.6±0.1 g/cm3

    Refractive Index:

    1.724

    Vapor Pressure:

    6X10-21 mm Hg at 25 deg C at 25 deg C /Estimated/

    Henrys Law Constant:

    Henry's Law constant: 2.08X10-29 atm-cu m/mole at 25 °C /Estimated/

    Dissociation Constants:

    pKa1 = 3.6; pKa2 = 4.4 (carboxylic moieties) /Estimated/

    Experimental Properties:

    White to almost white solid. /Disodium salt/|Hydroxy radical reaction rate constant = 2.4X10-10 cu cm/molec-sec at 25 °C /Estimated/

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Carcinogenicity, Category 2

    Reproductive toxicity, Category 1A

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H302 Harmful if swallowed

    H351 Suspected of causing cancer

    H360 May damage fertility or the unborn child

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P203 Obtain, read and follow all safety instructions before use.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P318 IF exposed or concerned, get medical advice.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Terbinafine hydrochloride,Carboplatin,Pramipexole dihydrochloride Monohydrate,Cisatracurium Besylate,Rivaroxaban,Lenvatinib

    Location:

    NO.28 SangYuan Rd,JinanCity,ShanDong Province,China

    Payment Terms:

    TT against copy of documents,D/P,L/C,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    1

    Total Annual Revenue:

    $50 million-$100 million

    Total Employees:

    501-1000

    Year of Establishment:

    2005

  • Country Product Purchase Quantity Date Posted
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