Humanin, HUMANIN TRIFLUOROACETATE 99% White powder C119H204N34O32S2 Senwayer

Humanin (HN) is a cytoprotective 24 amino acid peptide which was originally isolated from a cDNA library constructed from nervous tissue of a patient with familial Alzheimer’s disease (AD). Since then, it has been identified in different species such as mice, nematodes and rats (Niikura et al., 2004). The rat humanin homolog rattin (HNr) is a 38 amino acid peptide encoded and translated from an open reading frame (ORF) within the mitochondrial 16S ribosomal RNA (rRNA) gene (Caricasole et al., 2002; Paharkova et al., 2015).

Drawing from clinical research, there are a number of benefits of humanin peptide. Even though research is limited regarding humanin benefits, there’s still sufficient research to confirm the following effects of this peptide.

Longevity
Research has shown, Growth hormone (GH) negatively impacts HN peptide levels. For instance, research shows[iii] that mice who could not produce sufficient amounts of GH had higher levels of HN and lived longer than mice who did not produce adequate GH.

Additional research shows that animals of centenarians have 3x higher amounts of humanin than controls.

What’s more, HN can control cell death, enhance insulin sensitivity, lower inflammation, inhibit cell death, and degrade atherosclerotic plaques.

This suggests that humanin supplement may enhance longevity, as recent tests showed.

Neuroprotection
Research in rats[iv] shows that humanin protects against programmed cell death in specific situations. For example, the peptide can protect neurons in the setting of Alzheimer’s disease, preventing cell death caused by beta-amyloid plaque build-up. Studies also indicate that humanin protects against excitotoxic neuron death in research using NMDA pulses.

Scientists hope that humanin function in treating neurodegenerative disease like AD and other forms of dementia could be a near-future treatment with more robust research.

Clinical trials show that humanin protects neurons through two different mechanisms. Both of these mechanisms prevent mitochondria from stimulating the apoptosis pathway. By binding to the Bcl-2 stimulating proteins tBid and Bid, humanin blocks their function and closes down the apoptosis pathway.

New research from Argentina indicates that humanin is released by astrocytes to guard synapses in hippocampal neurons. Research has shown that humanin supplementation can be highly beneficial for older animals in preventing age-related declines like memory loss.

Insulin Resistance
According to scientific research, HN can also inhibit pancreatic beta-cell death and enhance glucose tolerance in non-diabetic animal subjects. This suggests that humanin for diabetes type 1 and type 2 could be beneficial.

Additionally, humanin acts on the hypothalamus, increasing insulin sensitivity in the liver and balancing blood glucose levels, as tests showed.

In turn, humanin can treat obesity by preventing weight gain through increased glucose stimulated insulin release, recent studies showed.

Heart Disease
Research reveals that humanin peptide helps to protect blood vessels from the aftermath of bad cholesterol, otherwise known as oxidized LDL cholesterol. It also interacts with the creation of free radicals in response to LDL oxidation, reducing the species in the vasculature by 50%. Interestingly, it also lessens apoptosis by 50%.

Because humanin levels decline with age, it is crucial to keep them stable in order to protect your health. New research shows that peptide humanin can serve as a diagnostic marker and a treatment for cardiovascular disease.

By enhancing AMPK and eNOS, Humanin can also ward off damage induced by left coronary occlusion, reducing oxidative stress in the body.

Bone Health
Scientists have found that humanin usage may be beneficial to bones in two primary ways. The first way is by preventing the death of chondrocytes – the cells responsible for keeping bones strong. Simultaneously, humanin results in promoted chondrocyte development, reducing osteoclast formation. To sum up, osteoclasts are the cells that break down bone and romodel it. Over-activation of these cells leads to severe bone loss. So by preventing this formation, humanin supplements help reduce significant bone remodeling and loss, as studies showed.

Eye Health
According to research, humanin plays a huge role in protecting the retinal pigment epithelium (RPE) in age-related Macular Degeneration (AMD). Of all the humanin health benefits, this one is quite significant from what clinical evidence suggests.

The RPE is a layer of the retina that nourishes the cells responsible for vision. It also absorbs lights, filters blood components in the eye, and establishes a healthy nature of the inner eye.

Humanin prevents AMD by protecting against oxidative stress and cell death of RPE by heightening mitochondrial levels.

Supplementation with humanin can allegedly improve RPE function and enhance the tissue’s resitance to apoptosis. With more mice trials, scientists hope that they can establish a more effective treatment for retinal diseases like AMD.

Fortunately, humanin is a safe chemical with minimal side effects, as studies showed. The research may be limited and it may not be legal to buy for consumption, but scientists do consider humanin safety to be high.

Please note, it may have negative effects in cancer and pregnant mice.

In terms of humanin effects on cancer, it may contribute to certain cancers such as prostate cancer, bladder cancer, and pituitary cancer.

In terms of humanin pregnancy effects, high HN levels are often seen in females mice with pre-eclampsia. This may be due to high levels of oxidative stress in the body.

1 mg twice a day. Humanin’s half-life in the body is about 30 minutes. Given the short half-life, the twice-a-daily protocol seemed better

To my knowledge there is no well-established human dose for humanin. Many animal studies administered higher dosages than human equivalent of 2 mg/d at my body weight of 58 kg. The daily 2 mg dosage was a balance between the safety, assumed effectiveness, and budget.