Palmitoyl Pentapeptide-4 /Matrixyl Acetate 98% White Powder C39H75N7O10 Senwayer

Palmitoyl Pentapeptide-4 is a pentapeptide, synethsized chain protein created by linking five amino acid peptides. This chain creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG), according to research. Palmitoyl Pentapeptide-4 is a small molecule that penetrates the skin easily and is structurally similar to the precursor of collagen type I. It is thought that pentapeptides can communicate with a cell and program it to do specific things, including repair work.

Palmitoyl Pentapeptide-4 is considered to be as effective against wrinkles as retinol, but less irritating. According to SmartSkinCare.com, “One study found that Palmitoyl Pentapeptide-4 was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects. Most other studies showed at least some improvement in various objective and subjective measures of wrinkles.”

Palmitoyl Pentapeptide-4 was developed by the corporations Sederma SA and Proctor & Gamble and originally named Palmitoyl Pentapeptide-3, but later renamed to Palmitoyl Pentapeptide-4 to reflect a correction in the data on its molecular structure, according to research. It is also included in many commercial formulas under the trademark of Matrixyl.

Palmitoyl Pentapeptide-4 is a pentapeptide, synethsized chain protein created by linking five amino acid peptides. This chain creates a response in the dermis of the skin that stimulates collagen and elastin fibroblasts, developing fibronectin (FN) and glycosaminoglycans (GAG), according to research. Palmitoyl Pentapeptide-4 is a small molecule that penetrates the skin easily and is structurally similar to the precursor of collagen type I. It is thought that pentapeptides can communicate with a cell and program it to do specific things, including repair work.

Palmitoyl Pentapeptide-4 is considered to be as effective against wrinkles as retinol, but less irritating. According to SmartSkinCare.com, "One study found that Palmitoyl Pentapeptide-4 was as effective as retinol in repairing sun-damaged skin but was devoid of side-effects. Most other studies showed at least some improvement in various objective and subjective measures of wrinkles."

Independent in vitro studies (unlike most studies available on Palmitoyl Pentapeptide-4, which have been done by P&G, originators of Matrixyl) demonstrated an increase in synthesis of Collagen I by 212%, Collagen IV by 100 to 327% and Hyaluronic Acid by 267%. Collagen I is predominant among the 19 forms of collagen found in the human body; therefore increasing production of Collagen I has a very dramatic effect on rebuilding the skin. Six month in vivo studies showed mean wrinkle depth was reduced by 17%, surface area containing deep wrinkles was reduced by 68%, surface area containing moderate wrinkles was reduced by 51% and skin roughness by 16%.

The EWG gives Palmitoyl Pentapeptide-4 a zero rating based on 100% data gap. No studies were found that noted harmful side effects or safety warnings regarding its use. However, independent studies of this ingredient are rare.

This peptide is best for targeted application on spots where you have deep folds or creases that have formed due to repetitive muscle movement—the crinkles around your eyes, the ‘11’ between your brows, and forehead wrinkles are all ideal spots. Because the final formulation of each individual product can vary drastically, follow product instructions for how often to use it.