Ozagrel hydrochloride
78712-43-3
industrial Grade
98%
SHANGHAI
KieRay Chem
25kg/drum
Yes
2022-12-31
fine chemicals,pharmaceutical materials
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceOzagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane A2 (TXA2) synthetase (IC50 = 4 nM). It does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase, or PGE2 isomerase (IC50 > 1 mM)[1]. Ozagrel HCl inhibits platelet aggregation in vitro[2] and arachidonate-induced arterial contraction in vivo. It protects against arachidonate-induced sudden death in rabbits[3] and alleviates liver injury induced by acetaminophen overdose in mice[4].
Ozagrel hydrochloride was initially developed jointly by Ono Pharmaceutical Co., Ltd. and Kissei Pharmaceutical Co., Ltd. in Japan. Approved for marketing in Japan in 1988, it became the world's first commercially available potent thromboxane A2 (TXA2) synthase inhibitor. This medication is primarily indicated for the treatment of patients with ischaemic cerebrovascular disease, as it exhibits dual effects of inhibiting platelet aggregation and dilating blood vessels, thereby effectively preventing thrombus formation.
ChEBI: Ozagrel hydrochloride is an organic molecular entity.Basic Info-
Product Name:
Ozagrel hydrochloride hydrate
Other Name:OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride;Ozagrel hydrate hydrochloride;Domenan;OKY-046 HCl;Vega;Ozagrel hydrochloride hydrate,(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate, OKY-046;(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid,hydrochloride (1:1);(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate
CAS No.:78712-43-3
Molecular Formula:C13H13ClN2O2
InChIKeys:OWIZTYOMGVTSDP-TXOOBNKBSA-N
Molecular Weight:264.71
Exact Mass:282.077118
EC Number:928-470-0
Color/Form:white to off-white
HScode:29332900
Categories:
Characteristics-
PSA:
55.1
Appearance:white to off-white solid
Melting Point:214-217°
Boiling Point:468°C at 760 mmHg
Flash Point:236.8ºC
Water Solubility:H2O: soluble
Critical Temperature & Pressure:under inert gas (nitrogen or Argon) at 2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
fine chemicals,pharmaceutical materials
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Location:
Room 260, Building 3, No. 76 Xingqiao North Road, Xingqiao Street, Yuhang District, Hangzhou City, Zhejiang Province, China
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2020
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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