Ozagrel hydrochloride hydrate
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Ozagrel hydrochloride hydrate
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CAS No:
78712-43-3
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Formula:
C13H13ClN2O2
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Chemical Name:
Ozagrel hydrochloride hydrate
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Synonyms:
OKY-046, (E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrate hydrochloride;Ozagrel hydrate hydrochloride;Domenan;OKY-046 HCl;Vega;Ozagrel hydrochloride hydrate,(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate, OKY-046;(2E)-3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid,hydrochloride (1:1);(E)-3-[4-(Imidazol-1-ylmethyl)phenyl]propenoic acid hydrochloride hydrate
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CAS No:
Description
Ozagrel HCl (78712-43-3) is a potent and selective inhibitor of thromboxane A2 (TXA2) synthetase (IC50 = 4 nM). It does not inhibit prostacyclin (PGI2) synthase, cyclooxygenase, or PGE2 isomerase (IC50 > 1 mM)[1]. Ozagrel HCl inhibits platelet aggregation in vitro[2] and arachidonate-induced arterial contraction in vivo. It protects against arachidonate-induced sudden death in rabbits[3] and alleviates liver injury induced by acetaminophen overdose in mice[4].
Ozagrel hydrochloride was initially developed jointly by Ono Pharmaceutical Co., Ltd. and Kissei Pharmaceutical Co., Ltd. in Japan. Approved for marketing in Japan in 1988, it became the world's first commercially available potent thromboxane A2 (TXA2) synthase inhibitor. This medication is primarily indicated for the treatment of patients with ischaemic cerebrovascular disease, as it exhibits dual effects of inhibiting platelet aggregation and dilating blood vessels, thereby effectively preventing thrombus formation.
ChEBI: Ozagrel hydrochloride is an organic molecular entity.
Ozagrel hydrochloride hydrate Basic Attributes
264.71
282.077118
928-470-0
white to off-white
29332900
Characteristics
55.1
white to off-white solid
214-217°
468°C at 760 mmHg
236.8ºC
H2O: soluble
under inert gas (nitrogen or Argon) at 2-8°C
Ozagrel hydrochloride hydrate Use and Manufacturing
Antithrombotic;Thromboxane synthase inhibitor
Ozagrel Hydrochloride is a selective thromboxane A2 synthase inhibitor, which alleviates liver injury induced by acetaminophen overdose in mice.
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