Urolithin A, 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one, Mitopure 98% white powder 1143-70-0 Senwayer

Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria. It belongs to the class of organic compounds known as benzo- coumarins or dibenzo-α- pyrones.

(1) Can extends lifespan

Urolithin A induces mitophagy by selectively eliminating damaged mitochondria. This also ensures recycling of mitochondria for optimal functioning. Mitochondria often get damaged with age and also due to stress. Getting rid of damaged mitochondria plays role in extending the lifespan.

In a study of worms, urolithin A supplement administered at 50 µM from the egg stage till death was found to extend their lifespan by 45.4%.

In another study conducted in 2019 using senescent human fibroblasts, urolithin A supplement was found to exhibit anti-aging potential. It was able to increase type 1 collagen expression and also reduce the expression of matrix metalloproteinase 1.

A small human study also show that UA was able to improve the mitochondrial function and skeletal health in elderly individuals when administered orally at 500-1000mg for a period of four weeks.

(2) Help prevent prostate cancer

The urolithins and their precursor, ellagitannins, possess anti-cancer properties. They are able to inhibit cancer-cell proliferation through cell cycle arrest and inducing apoptosis. Apoptosis refers to a programmed cell death in which the body eliminates potential cancer-cells and also other infected cells.

In a study of mice injected with human cancerous cells, ellagitannins metabolites (Urolithin A) were found to inhibit the growth of prostate cancer. The study further reported higher concentration of the metabolites in the prostate gland, colon and intestinal tissues.

(3) Cognitive enhancement

Urolithin A is able to protect neurons from death and can also trigger neurogenesis through anti-inflammatory signaling.

In a study of mice with memory impairment, urolithin A was found to ameliorate cognitive impairment and protect neurons from apoptosis. This suggest that UA can be used in treating Alzheimer’s disease (AD).

(4) Anti-obesity potential

Research show that ellagitannins are able to inhibit lipid accumulation and also adipogenic markers such as early growth response protein 2 as well as enhancer-binding protein through cell cycle arrest.

Urolithin A has been specifically found to improve insulin sensitivity thus prevents the development of obesity.

In a study of mice with induced obesity, urolithin A supplementation was found to prevent diet-induced obesity and metabolic impairment in mice. The study showed that UA treatment increased energy expenditure thus a lower body mass.

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