Zinc bacitracin

CBNumber： CB9127618
Name： ZINC BACITRACIN
MF： C66H101N17O16SZn
MW： 1486.06744
CAS： 1405-89-6

Feed additives:
Bacitracin zinc is a complex formed by bacitracin and zinc ions. It is a polypeptide antibiotic and is currently the most widely used antibiotic feed additive. The zinc content is generally 2% to 12%. The synthetic product is a white or slightly yellow powder with a special odor, easily deliquesced into a weakly alkaline substance, and easily soluble in water, methanol and ethanol. Bacitracin zinc has a strong antibacterial effect on gram-positive bacteria, and also has antibacterial activity on some gram-negative bacteria. The use of bacitracin zinc in swine full-price feed can promote growth rate, improve feed remuneration, and prevent swine bacterial diarrhea and chronic respiratory diseases. The addition concentration is generally effective at 10-100 mg/kg, and the effect is not significantly improved beyond this addition range. Bacitracin zinc is generally not absorbed in pig intestines, so there is no residual problem, and it is a safe and reliable antibiotic drug additive. Bacitracin zinc is highly toxic and is not easily absorbed by the intestine, so it cannot be used for the treatment of systemic infections.

Bacitracin:

Bacitracin is extracted from the culture medium of Bacillus licheniformis and is a polypeptide antibiotic. White or light yellow powder, odorless or slightly odorless, bitter in taste, hygroscopic. Easily soluble in water and ethanol, unstable, the aqueous solution is easy to be inactivated at room temperature, easy to precipitate when the pH value is less than 3, and unstable when the pH value is greater than 9. After dissolving, it should be refrigerated in the refrigerator. This product is calculated as a dry product, per mg The titer of bacitracin shall not be less than 55 bacitracin units. Bacitracin zinc is a bacitracin zinc salt, which is more stable than bacitracin. It is used as a feed additive to promote the growth and development of livestock and poultry, prevent intestinal infections, and improve feed returns. The dosage is the same as that of bacitracin. The antibacterial spectrum of bacitracin is similar to penicillin, and it has strong antibacterial effect on Gram-positive bacteria, but has no obvious effect on Gram-negative bacteria. For severe infections with drug-resistant Staphylococcus aureus. It is not absorbed when taken orally, and is used for intestinal infections. External use is also effective for body surface, oral and eye infections and mastitis caused by sensitive bacteria. Harmful to the kidneys. Bacitracin zinc has been used as a feed pharmaceutical additive. Oral administration is almost not absorbed, so it is generally believed that there is no drug residue problem in livestock and poultry products. This product is a narrow-spectrum antibiotic, mainly has a strong antibacterial effect on most gram-positive bacteria, is also effective on spirochetes and actinomycetes, but is ineffective on gram-negative bacilli. It has a synergistic effect with a variety of antibiotics such as penicillin G, streptomycin, neomycin, polymyxin, etc. Its zinc salt is mainly used as a feed additive, which has the functions of preventing intestinal infection, promoting growth, and improving feed remuneration. Fine Chemicalbook bacteria can slowly develop resistance to this product, but there is no cross-resistance between this product and other antibiotics. This product is highly toxic and cannot be administered by injection. It can be taken orally to treat bacterial diarrhea in livestock and treponemal dysentery in pigs. Clinically, it is often used in combination with a variety of antibiotics such as penicillin, streptomycin, neomycin, polymyxin B, etc. to enhance the curative effect. The above information is edited and organized by Chemicalbook Tongtong.

Function and use:

Polypeptide antibiotics have strong antibacterial effect on gram-positive bacteria, and also have antibacterial effect on a few gram-negative bacteria, spirochetes, actinomycetes and even penicillin-resistant staphylococci. The antibacterial mechanism is inhibition of bacterial cell wall formation and damage to bacterial cytoplasmic membrane. It can promote the growth of beneficial microorganisms in the intestine, increase the permeability of the intestinal mucosa, and promote the absorption of nutrients. It is mainly used to promote the growth of livestock and poultry, prevent and control bacterial diarrhea of ​​livestock and poultry and swine blood dysentery caused by Treponema. Bacitracin zinc is hardly absorbed when taken orally, and most of it is excreted with feces within 2 days, so it is not easy to remain in livestock and poultry products; bacteria rarely develop resistance to bacitracin, and there is no cross-resistance with other antibiotics, and with penicillin , streptomycin, neomycin, polymyxin, etc. have synergistic effects. This product is highly toxic and cannot be administered by injection. This product has incompatibility with olaquindox, guitarmycin, virginiamycin and enramycin.

Use as:

Feed additives are mainly used to promote the growth of livestock and poultry, prevent and control bacterial diarrhea of ​​livestock and poultry and swine blood dysentery caused by Treponema. Bacitracin zinc is hardly absorbed when taken orally, and most of it is excreted with feces within 2 days, so it is not easy to remain in livestock and poultry products; bacteria rarely develop resistance to bacitracin, and there is no cross-resistance with other antibiotics, and with penicillin , streptomycin, neomycin, polymyxin, etc. have synergistic effects. This product is highly toxic and cannot be administered by injection. This product has incompatibility with olaquindox, guitarmycin, virginiamycin and enramycin.

use:

Bacitracin zinc is a polypeptide antibiotic that has bactericidal effect on Gram-positive bacteria. Its mechanism is mainly to inhibit the bacterial wall synthesis of bacteria, and it can also bind to the cell membrane of sensitive bacteria, damage the integrity of the cell membrane, and lead to the outflow of important substances in the cell. Effectively inhibits Gram-positive bacteria and some Gram-negative bacteria; bacteria are resistant to bacitracin zinc at a slower rate, and there is no cross-resistance with other antibiotics.