Nootropics Cdp Choline Bulk Powder Citicoline CAS 987-78-0 Citicoline
HALAL ISO FDA 9 Inquiries
987-78-0
Pharmaceutical Grade
0%
Boil Bag
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Inquiry History
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Description
Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) & cytidine 5'-phosphocholine is a psychostimulant/nootropic. It is an intermediate in the generation of phosphatidylcholine from choline.
Citicoline is a precursor of phosphatidylcholine. As a type of phospholipid, phosphatidylcholine is an important component of cell membranes. When taken orally, Citicoline(CDP Choline) is metabolized to yield the free nucleotide, uridine and choline. Uridine and choline cross the blood-brain barrier, become incorporated into brain membrane phospholipids and increase the production of neurotransmitters in the central nervous system, including the synthesis of acetylcholine, and noradrenaline and dopamine. In the brain, Citicoline(CDP Choline) stabilizes the cell membranes and inhibits the formation of cytotoxic free fatty acids.
Certificate of Analysis:
Items
Standards
Results
Physical Analysis
Description
White Powder Complies Assay
99% 99.12% Mesh Size
100 % pass 80 mesh Complies Ash
≤ 5.0% 2.85% Loss on Drying ≤ 5.0% 2.85% Chemical Analysis Heavy Metal ≤ 10.0 mg/kg Complies Pb ≤ 2.0 mg/kg Complies As ≤ 1.0 mg/kg Complies Hg ≤ 0.1 mg/kg Complies Microbiological Analysis Residue of Pesticide Negative Negative Total Plate Count ≤ 1000cfu/g Complies Yeast&Mold ≤ 100cfu/g Complies E.coil Negative Negative Salmonella Negative Negative
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Citicoline can reduce the resistance of blood vessel of brain and accelerate substance metabolism of brain. It also can activate the mechanism of reticular formation of brain stem. It can be used in the therapy of acute craniocerebral trauma and disturbance of consciousness after brain operation.
The main indications of Citicoline are acute traumatic brain injury and brain consciousness after the operation. Moreover, Citicoline can treat central nervous system dysfunction and unconsciousness caused by acute injury, paralysis agitans, tinnitus and nerve deafness, and poisoning caused by sleeping pills. In recent years, Citicoline is widely used in clinical for treatment of ischemic stroke, cerebral arteriosclerosis, multiinfarct dementia, Alzheimer's disease, and children viral encephalitis.
1.Citicoline is a brain chemical that occurs naturally in the body.
2.As a medicine, Citicoline is taken by mouth as a supplement or given by IV or as a shot.
3.Citicoline is used for Alzheimer's disease and other types of dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson's disease, and glaucoma.
ECHEMI Editorial ReferenceCiticoline is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
Solid
CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It derives from a CDP. It is a conjugate base of a CDP-choline(1+).|Citicoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.|Citicoline is a nutritional supplement and source of choline and cytidine with potential neuroprotective and nootropic activity. Citicoline, also known as cytidine-5-diphosphocholine or CDP-choline, is hydrolyzed into cytidine and choline in the intestine. Following absorption, both cytidine and choline are dispersed, utilized in various biosynthesis pathways, and cross the blood-brain barrier for resynthesis into citicoline in the brain, which is the rate-limiting product in the synthesis of phosphatidylcholine. This agent also increases acetylcholine (Ach), norepinephrine (NE) and dopamine levels in the central nervous system (CNS). In addition, citicoline is involved in the preservation of sphingomyelin and cardiolipin and the restoration of Na+/K+-ATPase activity. Citicoline also increases glutathione synthesis and glutathione reductase activity, and exerts antiapoptotic effects.|Donor of choline in biosynthesis of choline-containing phosphoglycerides.CertificatesBasic Info-
Product Name:
Cytidine diphosphate choline
Other Name:Cytidine 5′-(trihydrogen diphosphate),P′-[2-(trimethylammonio)ethyl] ester,inner salt;Cytidine 5′-(trihydrogen diphosphate),P′-[2-(trimethylammonio)ethyl] ester,hydroxide,inner salt;Choline,hydroxide,5′-ester with cytidine 5′-(trihydrogen pyrophosphate),inner salt;Cytidine 5′-diphosphate choline;Citicoline;Cytidine diphosphate choline ester;Nicholin;Niticolin;Cereb;Colite;Nicolin;Recofnan;Ensign;Suncholin;CDP-choline;Cytidine diphosphate choline;Cytidine diphosphorylcholine;Cytidine diphosphocholine;Cytidine 5′-diphosphocholine;Cytidine 5′-(cholinyl pyrophosphate);Cytidine choline diphosphate;Cytidine 5′-(choline diphosphate);Choline 5′-cytidine diphosphate;Recognan;Choline cytidine diphosphate;Citicholine;Cytidoline;Citidoline;Somazina;Somazine;Reagin;Neucolis;Difosfocin;Sintoclar;Haocolin;Corenalin;Audes;Rexort;Citifar;Hornbest;Cyscholin;Emicholine F;NSC 122002;Cognizin;1477-47-0;64143-42-6;769081-33-6
CAS No.:987-78-0
Molecular Formula:C14H26N4O11P2
InChIKeys:InChIKey=RZZPDXZPRHQOCG-OJAKKHQRSA-N
Molecular Weight:488.32
Exact Mass:488.107330
EC Number:213-580-7
DSSTox ID:DTXSID9048431
NCI Thesaurus Code:C96743
ATC Code:N - Nervous system
HScode:2942000000
Categories:
Characteristics-
PSA:
214
XLogP3:-7.07
Appearance:Solid
Boiling Point:851.4°C at 760 mmHg
Toxicity:LD50 in mice, rats (mg/kg): 4600 ±335, 4150 ±370 i.v.; both species 8 g/kg orally (Grau)
Specific rotation:D25 +19.0° (c = 0.86 in H2O)
Collision Cross Section:197.6 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|200.64 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|198.86 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|208.98 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|208.41 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|198.3 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|207.8 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|205.9 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|210.2 Ų [M+Na-2H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|207.7 Ų [M-H]-
Hazard IdentificationClassification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
Pictogram(s) No symbol. Signal word No signal word
Hazard statement(s) none
Precautionary statement(s) Prevention none
Response none
Storage none
Disposal none
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Inquiry History9 Inquiries
Country Product Purchase Quantity Date Posted 
United States
CAS 987-78-0 Citicoline Cdp Choline
1 KG Oct 27, 2025 
India
Citicoline Base
500 KG Jun 27, 2025 
Mexico
Citicoline
1 KG Oct 15, 2025 
Poland
Citicoline Cdp Choline
50 KG Apr 29, 2024
Poland
CITICOLINE, CYTIDINE 5'-DIPHOSPHOCHOLINE,CDP-Coline 98.0% white or almost white crystalline powder
100 KG Sep 21, 2023 
Vietnam
citicoline
1 KG Jun 29, 2026
United States
Citicoline
100 G Apr 10, 2026 
South Korea
Citicoline
500 KG Sep 3, 2026 
Bangladesh
Butyl Acetate
1.00 KG Nov 11, 2025 Post an enquiry for this product
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