High Quality and Reasonable Price Saxagliptin 361442-04-8
HALAL ISO FDA 2 Inquiries
361442-04-8
Pharmaceutical Grade
0%
ZB
Foil Bag, Box, Drum
2022-12-31
Herb Extracts,Cosmetic raw materails,API
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Product Description
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Seller Information
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Inquiry History
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Description
Product Name: Saxagliptin
Synonyms:(1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-tricyclo[3.3.13,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo-[3.1.0]hexane-3-carbonitrile;Saxagliptin;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile;BMS 477118;Onglyza;Saxagliptin(BMS 477118);Saxagliptin 15ND2;(1S,3S,5S)-2-[(2S)-2-aMino-2-(3-hydroxyadaMantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
CAS:361442-04-8
MF:C18H25N3O2
Product Categories:Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;organic pharmaceutical;Inhibitors
Density: 1.35
Fp: 548.7ºC
Chemical Properties: White Solid
Uses: Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration an d has a pharmacokinetic profile compatible with once daily dosing .
Shacketine is a type 2 diabetes drug that can stimulate the pancreas to produce more in*sulin after the meal. It was reached by the cooperation of AstraZeneca and Bristol-Myers Squibb Company and belongs to DPP-IV inhibitor. It plays the role through inhibiting GLP-l degradation. GLP-I is the hormones naturally produced in the intestine after taking food. It can regulate the secretion of in*sulin and strengthen the utilization of glucose in the peripheral tissues. The single medication of Shacketine can improve blood glucose control and the combined medication of Shacketine with metformin, sulfonylurea and thiazolidinediones can enhance curative effect. It leads to low risk of hypoglycemia and its adverse reactions are similar to placebo, showing better tolerance .
On July 31, 2009, Shakleitine tablets , a new drug of type 2 diabetes, jointly researched and developed AstraZeneca and Bristol-Myers Squibb was approved by the US FDA. It can be taken once a day to treat type 2 diabetes combined with controlling Diet and exercise. The most common side effects are upper respiratory tract infections, urinary tract infections and headaches. And other side effects include allergic reactions, such as rash and urticaria .
Customers Reviews
CertificatesBasic Info-
Product Name:
Saxagliptin
Other Name:2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,(1S,3S,5S)-;2-Azabicyclo[3.1.0]hexane-3-carbonitrile,2-[(2S)-amino(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-,(1S,3S,5S)-;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile;BMS 477118;Saxagliptin;BMS 477118-11;Onglyza;1339955-48-4
CAS No.:361442-04-8
Molecular Formula:C18H25N3O2
InChIKeys:InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N
Molecular Weight:315.414
Exact Mass:315.41
EC Number:1308068-626-2
DSSTox ID:DTXSID7048580
ATC Code:A10BD|A10BD21|A10BH03|A - Alimentary tract and metabolism
HScode:2933990090
Categories:
Characteristics-
PSA:
90.35000
XLogP3:1.79618
Density:1.35
Boiling Point:548.7ºC at 760mmHg
Flash Point:548.7℃
Refractive Index:1.640
Water Solubility:In water, 791.8 mg/L at 25 °C (est)
Storage Conditions:Store at 20 deg - 25 °C (68 deg - 77 °F); excursions permitted to 15 deg - 30 °C (59 deg - 86 °F).
Vapor Pressure:4.19X10-11 mm Hg at 25 °C (est)
Henrys Law Constant:Henry's Law constant = 1.11X10-18 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa = 7.90 (est)
Experimental Properties:White to yellow or light brown, non-hygroscopic, crystalline powder; sparingly soluble in water at 24 °C; slightly soluble in ethyl acetate; soluble in methanol, ethanol, isopropyl alcohol; acetonitrile, acetone, and polyethylene glycol 400 /Saxagliptin monohydrate/|Hydroxyl radical reaction rate constant = 6.46X10-11 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Herb Extracts,Cosmetic raw materails,API
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Location:
1403,Jinye B Block
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Payment Terms:
TT against copy of documents
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Average lead Time:
8
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2015
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
Saxagliptin
1500.00 G Apr 20, 2026
India
Saxagliptin
10 G Apr 1, 2026 Post an enquiry for this product