PRN-1371
1802929-43-6
Industrial Grade
99%
Dideu
25kg/Cardboard Drum
Yes
2022-12-31
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial Referencepan FGFR Inhibitor PRN1371 is a highly specific covalent inhibitor of human fibroblast growth factor receptor types 1, 2, 3 and 4 (FGFR1-4) with potential antiangiogenic and antineoplastic activities. FGFR1-4 tyrosine kinase inhibitor PRN1371 specifically binds to a conserved cysteine residue in the glycine-rich loop in FGFRs and inhibits their tyrosine kinase activity, which may result in the inhibition of both tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases, which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation, proliferation and survival, and in tumor angiogenesis. This agent potently inhibits FGFR1-4 but does not inhibit other tyrosine kinases, even those that share the conserved cysteine, which may improve therapeutic responses and decrease toxicity when compared with less selective inhibitors.Basic Info
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Product Name:
8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Other Name:PRN1371;1802929-43-6;PRN-1371;UNII-S3OPE9IA3Q;S3OPE9IA3Q;8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one;6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one;GTPL9788;CHEMBL4068509;SCHEMBL16993012
CAS No.:1802929-43-6
Molecular Formula:C26H30Cl2N6O4
InChIKeys:PUIXMSRTTHLNKI-UHFFFAOYSA-N
Molecular Weight:561.5
Exact Mass:560.1705588
UNII:S3OPE9IA3Q
NCI Thesaurus Code:C124931
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
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