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Isopropanol

Isopropanol structure

CAS No:
67-63-0
Formula:
C3H8O
Chemical Name:
Isopropanol
Synonyms:
2-Propanol;Isopropyl alcohol;Avantine;Dimethylcarbinol;Isohol;Isopropanol;Lutosol;PRO;Petrohol;sec-Propyl alcohol;Alcosolve 2;iso-Propanol;1-Methylethyl alcohol;Imsol A;Combi-Schutz;Alcojel;Avantin;Hartosol;Propol;Takineocol;n-Propan-2-ol;2-Hydroxypropane;2-Propyl alcohol;Sterisol Hand Disinfectant;1-Methylethanol;iso-Propyl alcohol;sec-Propanol;IPA;Autosept;IPS 1 (alcohol);IPS 1;Virahol;Tokuso IPA;NSC 135801;Steri-Fab;isopropanol;8013-70-5
Categories:
Cosmetic Ingredient > Dissolving Agent

Description

Isopropyl alcohol is a clear, colorless, mobile, volatile, flammable liquid with a characteristic, spirituous odor resembling that of a mixture of ethanol and acetone; it has a slightly bitter taste.It is miscible with water, ethyl ether, and ethyl alcohol. Isopropyl alcohol is incompatible with strong oxidizers, acetaldehyde, chlorine, ethylene oxide, acids, and isocyanates.

Isopropyl alcohol (IUPAC name propan-2-ol), also called isopropanol or dimethyl carbinol, is a compound with the chemical formula C3H8O or C3H7OH or CH3CHOHCH3 (sometimes represented as i-PrOH). It is a colorless, flammable chemical compound with a strong odor. As a propyl group linked to a hydroxyl group, it is the simplest example of a secondary alcohol, where the alcohol carbon atom is attached to two other carbon atoms, sometimes shown as (CH3)2CHOH. It is a structural isomer of 1-propanol. It has a wide variety of industrial and household uses.

Isopropanol Basic Attributes

Molecular Weight：

60.09500

Exact Mass：

60.10

EC Number：

200-661-7

Freezing Point：

-89.5℃

HScode：

2905122000

Characteristics

PSA：

20.23000

XLogP3：

0.3871

Appearance：

Colourless liquid

Density：

0.78505 g/cm³ @ Temp: 20 °C

Melting Point：

-88.5 °C

Boiling Point：

82.5 °C @ Press: 760 Torr

Flash Point：

53 °F

Refractive Index：

n20/D 1.377(lit.)

Water Solubility：

Micible with water.

Storage Conditions：

Storage Room low temperature ventilation drying ,Separate storage with oxidizing agents and acids

Vapor Pressure：

Vapour pressure, kPa at 20°C: 4.4

Vapor Density：

2.1 (vs air)

Toxicity：

LD50 orally in rats: 5.8 g/kg (Smyth, Carpenter)

Flammability characteristics：

Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F.

Explosive limit：

vol% in air: 22

Odor：

Pleasant odor

Taste：

Slightly bitter taste

PKA：

17.1None

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 1219 3/PG 2

wgk germany：

hazard class code：

R11; R36; R67; R40; R10; R36/38

safety instructions：

S7-S16-S24/25-S26-S36/37

RTECS Number：

NT8050000

Marks：

Storage features：

Fireproof. Separated from strong oxidants. Cool. Well closed.

Stability/Shelf Life：

Preserve in tight containers, remove from heat.

Precautionary statement(s)：

P210-P261-P305 + P351 + P338

Hazard Statements：

H225-H319-H336

RIDADR：

UN 1219

Caution Statement：

P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235

Isopropanol Use and Manufacturing

Methods of Manufacturing

Propylene system of isopropyl alcohol, the process:
1 Indirect hydration method.
More than 50% propylene raw material gas is passed into the absorption tower, and is absorbed with 75% -85% concentrated sulfuric acid at 50 ℃ and low pressure to produce isopropyl hydrogen sulfate. Water was added to dilute the absorbing solution to a sulfuric acid content of 35%. The isopropyl alcohol was then hydrolyzed in the desorption column with low pressure steam to produce isopropyl alcohol. The crude distillation tower to isopropanol and water azeotropic composition, containing about 87% of isopropyl alcohol. And then continue to use distillation tower steamed to 95%, with benzene extraction, separation of water and then distillation, can be obtained with more than 99% isopropanol products.
2 Direct hydration of propylene.
Water were pressurized to 1.96MPa, and preheated to 200 ° C, after mixing into the reactor, the hydration reaction reactor equipped with diatomite catalyst, the reaction temperature is 95 ° C, the pressure is 0.96 MPa, the molar ratio of water to propylene was 0.7: 1, the one-way conversion of propylene was 5.2% and the selectivity was 99%. The reaction gas is sent to a high-pressure cooler and a high-pressure separator after being neutralized and heat-exchanged. The isopropanol in the gas phase is sprayed and recovered by deionized water in a recovery tower, and the gas of the reaction is recycled after being pressurized by a circulating compressor ( Keeping the propylene content in the recycle system at 85%). (15% -17%), the crude distillation tower was 85% -87% distillation of isopropanol aqueous solution, and then evaporated to 95% by distillation tower, and then extracted with benzene concentration to 99% or more.

Uses

1. When compared to ethanol, 50% less is required for nucleic acid precipitation, thus minimizing the total volume to be centrifuged for DNA or RNA recovery.
2. Suitable for HPLC, spectrophotometry, environmental testing

Computed Properties

Molecular Weight:60.10
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:60.057514874
Monoisotopic Mass:60.057514874
Topological Polar Surface Area:20.2
Heavy Atom Count:4
Complexity:10.8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Synthesis Route

1014720-73-0

1002-26-2

80136-05-6

104803-80-7

Material

Diisopropyl ether

Propylene

Phosphonic acid

Glycerol

Propylene Glycol

Acetic acid

Acetone

Propane

Propylene Oxide

Phosphoric acid

Downstream Products

Diisopropyl ether

Isopropyl acetate

1-Methylethyl 2-cyanoacetate

Aluminum isopropoxide

Price Analysis

Make your Isopropanol purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Isopropanol prices .

Data: 2026-08-21
Price: 7441.66Yuan/mt
Change: 66.66

Drug Function and Efficacy

This product is a prostaglandin synthesis inhibitor with anti-inflammatory and analgesic effects. For local application, its active ingredients can penetrate the skin to reach the inflamed area, relieve acute and chronic inflammatory reactions, reduce inflammatory swelling, and relieve pain.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Diclofenac diethylamine emulsion
Ingredients	Each vial of this product contains 0.5 grams of diclofenac diethylamine (calculated as diclofenac sodium) and excipients such as isopropyl alcohol and propylene glycol.
Indication	1. There is no report of interaction with other drugs. 2. If used with other drugs at the same time, drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	50g/piece

Clindamycin phosphate topical solution
Ingredients	Each bottle of this product contains 0.3 grams of clindamycin. Excipients are: ethanol, propylene glycol, isopropanol and menthol.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	30ml:0.3g (calculated as clindamycin)
Manufacturer	Shenzhen Daphne Pharmaceutical Co., Ltd.

Ibuprofen gel
Ingredients	This product contains 50 mg of ibuprofen per gram, and the excipients are: carbomer, propylene glycol, isopropyl alcohol, menthol, ethylparaben, triethanolamine, and purified water.
Indication	If you are using other medicines, please consult your physician or pharmacist before using this product.
Specifications	15g:0.75g
Manufacturer	Hubei Kangzheng Pharmaceutical Co., Ltd.

Registered Holders

Tianjin Yongkang Pharmaceutical Co., Ltd.

China
Active
Luofu Pharmaceutical Technology (Shanghai) Co., Ltd.

China
Active
Jiangxi Yipusheng Pharmaceutical Co., Ltd.

China
Active

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