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Home > Pharmaceutical Intermediates > Antidepressants > Oxcarbazepine for Sale > Oxcarbazepine Anti depressant 99% white powder 1 hk
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Oxcarbazepine Anti depressant 99% white powder 1 hk

GMP ISO

Unit Price: Get Latest Price
CAS No.:

28721-07-5

Grade:

UPS

Content:

99%

Port:

shanghai

Brand:

hk

Packaging:

1kg/package

Sample Available:

Yes

Price valid (until):

2022-06-21

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,D/P,L/C,O/A,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

pharmaceutical intermediates

  • Product Description

  • Seller Information

  • Description

    Whatsapp:+86 166 2280 2789

    Wickr:pharmmona


    PROFESSIONAL SUPPLIER

    Tianjin Fengyuan Biotech Co.,LTD is a large incorporated industry manufacturers and supplier of advanced refined raw materials .


    We focus on manufacture Pharm & chemical products. Our factory is located in Tianjin with 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, which are capable to independently research and develop kinds API standard pharmaceutical intermediates.


    Customer satisfaction is our company′s mission, and our object is to produce more better products.Customized synthesis services for all kinds of organic intermediate , catalyst ligands and impurities.



     

    50,000 square meters for Production.

    1,288 customers we have in the world

     


    QUALITY ASSURANCE

    We pursuing the best chemical technology.

    No matter how the market changes and intense competition, we'll still provide a high standard of professional services by virtue of honesty and professional strengths.




    You can get free samples for some products, only need to pay the shipping cost. You can send us your product specifications and requests, we will manufacture the products according to your requests. Please contact to our salesmen to get more details.


    ADVANCED TECHOLOGY

    Our company has established a reaserch center. The center has advanced equipment, multiple functions lab and experienced technical team; We always pay attention to absord "fresh blood", constantly introduce talents, and enhance team′s cooperation. So far, the company has cultivated a group of experienced R& D team. The research team is constantly develop new products, and reduce production cost, made the outstanding contribution for the company′s development and future.




    We also have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling. Various Detection Device is equipped in the company, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.


    e product introduction information...

    ECHEMI Editorial Reference
    Oxcarbazepine is structurally a derivative of carbamazepine; used for the treatment of partial seizures in epileptic children and adults
    [1]
    . Compared with carbamazepine, it contains an extra oxygen atom to the benzylcarboxamide group, reducing the impact on the liver of metabolizing the drug, and also preventing the serious forms of anemia occasionally associated with carbamazepine, further reducing potential side effects, it is thought to have the same mechanism as carbamazepine - so
    Solid
    Oxcarbazepine is a dibenzoazepine derivative, having a carbamoyl group at the ring nitrogen, substituted with an oxo group at C-4 of the azepeine ring which is also hydrogenated at C-4 and C-5. It is a anticholinergic anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It has a role as an anticonvulsant and a drug allergen. It is a dibenzoazepine and a cyclic ketone. It contains a carbamoyl group.|Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000. It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine]. Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.|Oxcarbazepine is an Anti-epileptic Agent. The physiologic effect of oxcarbazepine is by means of Decreased Central Nervous System Disorganized Electrical Activity.|Eslicarbazepine is an aromatic anticonvulsant similar to oxcarbazepine that is used in combination with other antiepileptic agents as therapy of partial onset seizures. Eslicarbazepine is associated with a low rate of transient serum enzyme elevations during therapy and has been implicated in rare instances of clinically apparent liver injury.|Oxcarbazepine is a keto analogue of carbamazepine and, like the parent drug, is a potent anticonvulsant used alone or in combination with other agents in the therapy of partial seizures. Oxcarbazepine has been linked to rare instances of clinically apparent acute drug induced liver injury which resembles carbamazepine hepatotoxicity.|Oxcarbazepine is a dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.|A carbamazepine derivative that acts as a voltage-gated sodium channel blocker. It is used for the treatment of PARTIAL SEIZURES with or without secondary generalization. It is also an inducer of CYTOCHROME P-450 CYP3A4.

    Certificates

    Basic Info
    Product Name:

    Oxcarbazepine

    Other Name:

    5H-Dibenz[b,f]azepine-5-carboxamide,10,11-dihydro-10-oxo-;10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxamide;GP 47680;Oxcarbazepine;Trileptal;Oxacarbazepine;Oxecarb;Oxetol;Aurene;Tolep;Timox;Oxtellar;10-Oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide;10-Oxo-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide

    CAS No.:

    28721-07-5

    Molecular Formula:

    C15H12N2O2

    InChIKeys:

    InChIKey=CTRLABGOLIVAIY-UHFFFAOYSA-N

    Molecular Weight:

    252.27

    Exact Mass:

    252.27

    EC Number:

    249-188-8

    UNII:

    VZI5B1W380

    NSC Number:

    758693

    DSSTox ID:

    DTXSID0045703

    NCI Thesaurus Code:

    C47643

    Color/Form:

    Crystals from ethanol|White to faintly orange crystalline powder

    ATC Code:

    N - Nervous system

    HScode:

    29339900

    Categories:

    Antidepressants

    Characteristics
    PSA:

    63.4

    XLogP3:

    1.7

    Appearance:

    white solid

    Density:

    1.329±0.06 g/cm3(Predicted)

    Melting Point:

    215.5 °C

    Boiling Point:

    457.2°C at 760 mmHg

    Flash Point:

    2℃

    Refractive Index:

    1.661

    Water Solubility:

    soluble in DMSO(~9 mg/mL), methanol, water, ethanol and acetone.

    Storage Conditions:

    Store at RT

    Vapor Pressure:

    7.6X10-9 mm Hg at 25 deg C (est)

    PKA:

    13.73None

    Henrys Law Constant:

    Henry's Law constant = 6.9X10-13 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    13.73|pKa = -0.65 (est)

    Collision Cross Section:

    153.8 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|152.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.8X10-11 cu cm/molec-sec at 25 °C (est)

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    Acute toxicity - Category 4, Dermal

    Acute toxicity - Category 4, Inhalation

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    H312 Harmful in contact with skin

    H332 Harmful if inhaled

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P317 Get medical help.

    P321 Specific treatment (see ... on this label).

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store at 25 Deg C (77 deg F); excursions permitted to 15 to 30 deg C (59 deg F).

  • Seller Information
    Business Type:

    Trader

    Main Products:

    pharmaceutical intermediates

    Location:

    288 Hongqi Road

    Payment Terms:

    TT against copy of documents,D/P,L/C,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    Less than $1 million

    Total Employees:

    11-50

    Year of Establishment:

    2020

    Tianjin Jinyuan Biotechnology company is a leading Trader supplier of Oxcarbazepine, 2-Isopropyl-4-methylpyridin-3-amine, Esomeprazole sodium based in Districts, Tianjin, China. With a commitment to quality and customer satisfaction, Tianjin Jinyuan Biotechnology company has become a trusted name in the industry. Our product line includes a range of high-quality Oxcarbazepine, 2-Isopropyl-4-methylpyridin-3-amine, Esomeprazole sodium, which are available at competitive prices. Tianjin Jinyuan Biotechnology company has established itself as a reliable supplier of chemical products on the echemi.com.

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