VALDECOXIB 99% Pharm Intermediate Professional Producer Greenbo
181695-72-7
Pharmaceutical Grade
99%
Shanghai
Greenbo
25kg Drum
Yes
2022-07-31
Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceWhite Crystalline PowderChEBI: A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammator drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.Valdecoxib is a second-generation COX-2 inhibitor, devel
Solid
Valdecoxib is a member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke. It has a role as a non-steroidal anti-inflammatory drug, a cyclooxygenase 2 inhibitor, a non-narcotic analgesic, an antirheumatic drug and an antipyretic. It is a member of isoxazoles and a sulfonamide.|Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.|Valdecoxib is a sulfonamide derivative and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic activities. Valdecoxib selectively binds to and inhibits cyclooxygenase (COX)-2, thereby preventing the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and therefore does not interfere with blood coagulation.Basic Info-
Product Name:
Valdecoxib
Other Name:Benzenesulfonamide,4-(5-methyl-3-phenyl-4-isoxazolyl)-;4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide;SC 65872;Valdecoxib;4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide;Bextra;Valecoxib;Valus;Valz;Vx 2;Valdyn
CAS No.:181695-72-7
Molecular Formula:C16H14N2O3S
InChIKeys:InChIKey=LNPDTQAFDNKSHK-UHFFFAOYSA-N
Molecular Weight:314.36
Exact Mass:314.36
EC Number:448-010-8
UNII:2919279Q3W
NSC Number:759846
DSSTox ID:DTXSID6044226
NCI Thesaurus Code:C1869
Color/Form:White crystalline powder
ATC Code:M01AH03|M - Musculo-skeletal system
HScode:2935009090
Categories:
Characteristics-
PSA:
94.6
XLogP3:2.6
Appearance:white to off-white
Density:1.303±0.06 g/cm3(Predicted)
Melting Point:172-173 °C
Boiling Point:481.2±55.0 °C(Predicted)
Flash Point:244.8±31.5 °C
Refractive Index:1.609
Water Solubility:DMSO: >25mg/mL
Storage Conditions:Store at RT
Vapor Pressure:4.6X10-10 mm Hg at 25 deg C /Estimated/
Henrys Law Constant:Henry's Law constant = 2.2X10-11 atm-cu m/mol at 25 °C /Estimated/
Experimental Properties:Hydroxyl radical reaction rate constant = 1.3X10-11 cu cm/molec-sec at 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
H373 May cause damage to organs through prolonged or repeated exposure
H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
Response P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Active Pharm Ingredients,Chemical Catalyst,Pharmaceutical Intermediates,Flavors and Fragrances,Agrochemicals,Chemical Pesticides
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Location:
Zone K,Zwei Tianyuan Dushi Est,New Industial Park,High-tech Zone, Xian City,Shaanxi
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
15 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
11-50
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Year of Establishment:
2017
Company Certificates-
international trade license
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FSSC2000
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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