EMETINE
483-18-1
Industrial Grade
99%
25kg/Cardboard Drum
Yes
2022-07-27
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceEmetine is an anti-protozoal drug previously used for intestinal and tissue amoebiasis[1].
Emetine is a pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. It has a role as an antiprotozoal drug, a plant metabolite, an antiviral agent, an emetic, a protein synthesis inhibitor, an antimalarial, an antineoplastic agent, an autophagy inhibitor, an antiinfective agent, an expectorant, an anticoronaviral agent and an antiamoebic agent. It is a pyridoisoquinoline and an isoquinoline alkaloid. It derives from a cephaeline. It is a conjugate base of an emetine(2+). It derives from a hydride of an emetan.|The principal alkaloid of ipecac, from the ground roots of Uragoga (or Cephaelis) ipecacuanha or U. acuminata, of the Rubiaceae. It is used as an amebicide in many different preparations and may cause serious cardiac, hepatic, or renal damage and violent diarrhea and vomiting. Emetine inhibits protein synthesis in EUKARYOTIC CELLS but not PROKARYOTIC CELLS.Basic Info-
Product Name:
(-)-Emetine
Other Name:2H-Benzo[a]quinolizine,3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-,(2S,3R,11bS)-;Emetine;Emetan,6′,7′,10,11-tetramethoxy-;(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-2H-benzo[a]quinolizine;(-)-Emetine;NSC 33669;Emetin;Cephaeline methyl ether;602-59-5;24377-67-1;888715-16-0
CAS No.:483-18-1
Molecular Formula:C29H40N2O4
InChIKeys:InChIKey=AUVVAXYIELKVAI-CKBKHPSWSA-N
Molecular Weight:480.649
Exact Mass:480.64
EC Number:207-592-1
UNII:X8D5EPO80M
DSSTox ID:DTXSID5022980|DTXSID4041024|DTXSID80424947
Color/Form:WHITE AMORPHOUS POWDER
ATC Code:P - Antiparasitic products, insecticides and repellents
Categories:
Characteristics-
PSA:
52.2
XLogP3:6.01210
Density:1.17g/cm3
Melting Point:74 °C
Boiling Point:600.3ºC at 760mmHg
Flash Point:316.9ºC
Water Solubility:SPARINGLY SOL IN WATER, PETROLEUM ETHER, IN SOLN OF POTASSIUM OR SODIUM HYDROXIDE; FREELY SOL IN METHANOL, ETHYL ACETATE
Storage Conditions:-20°C Freezer
Toxicity:LD50 i.p. in rats: 12.1 mg/kg (Radomski)
Specific rotation:D20 -50° (c = 2 in CHCl3)
Taste:Very bitter taste
PH:STRONG ALKALINE REACTION
Dissociation Constants:PK1 5.77; PK2 6.64|DIACIDIC BASE: K1 = 1.7X10-6; K2 = 2.3X10-7
Collision Cross Section:219.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Contains water of crystallization varying from 3 to 8 H2O; clusters of needles after drying at 105 °C, MP: 235-255 °C (decomposition); specific optical rotation: +11 deg (concentration by volume = 1 g in 100 ml water); 1 g of the hydrated salt dissolves in about 7 ml water; pH of aq soln (1 g in 50 ml) 5.6; sol in alcohol. /Emetine dihydrochloride/
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7 days
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
Company Certificates-
ISO Certificate
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REACH
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