N,N'-dihexadecyl-N,N'-bis(2-hydroxyethyl)propanediamide
ISO
149591-38-8
Different Grade
99.9%
Amitychem
25kg/Drum
2026-10-14
chemicals
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Product Description
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Seller Information
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DescriptionAmitychem, with approximately 292678 visits to its shop, is a reputable Manufactory that has been providing N,N'-dihexadecyl-N,N'-bis(2-hydroxyethyl)propanediamide products for 7 years on ECHEMI.CertificatesBasic Info
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Product Name:
N1,N3-Dihexadecyl-N1,N3-bis(2-hydroxyethyl)propanediamide
Other Name:Propanediamide,N1,N3-dihexadecyl-N1,N3-bis(2-hydroxyethyl)-;Propanediamide,N,N′-dihexadecyl-N,N′-bis(2-hydroxyethyl)-;N1,N3-Dihexadecyl-N1,N3-bis(2-hydroxyethyl)propanediamide;Questamide H;Bishydroxyethyl biscetyl malonamide
CAS No.:149591-38-8
Molecular Formula:C39H78N2O4
InChIKeys:InChIKey=RHIIHYCQYFKTHL-UHFFFAOYSA-N
Molecular Weight:610.99446
Exact Mass:639.05
EC Number:422-560-9
UNII:913CU8H33E
Categories:
Characteristics-
PSA:
81.08000
XLogP3:9.98090
Density:0.945
Boiling Point:732.6±55.0 °C(Predicted)
Flash Point:396.86ºC
Refractive Index:1.484
Research-
Class:
Angiotensin IV-derived oligopeptide / HGF-c-Met potentiator
Status:Research compound — Not FDA approved
Mechanism:A synthetic, orally active, blood-brain-barrier-permeable oligopeptide (Hexanoyl-Tyr-Ile-Ahx-NH₂) derived from angiotensin IV. Dihexa binds hepatocyte growth factor (HGF) with high affinity (Kd = 65 pM) and allosterically potentiates HGF activity at its receptor c-Met, promoting dendritic spinogenesis and synaptogenesis. In preclinical models it was reported to be seven orders of magnitude more potent than BDNF at promoting synapse formation. Note: the foundational 2014 paper (McCoy AT, et al. Neurobiol Learn Mem. 2014) was retracted in 2025.
EC50 (HGF Binding KD):65 pM
Activity note:Dihexa is an HGF potentiator, not a direct receptor agonist. It does not activate c-Met alone but markedly augments HGF-induced c-Met activation at low nanomolar HGF concentrations. Functional synaptogenic activity was reported at 10⁻¹°–10⁻⁻ M (original data now subject to retraction).
Source:Original report: McCoy AT, et al. Neurobiol Learn Mem. 2014;115:112-120 (retracted 2025). Benoist CC, et al. J Pharmacol Exp Ther. 2014;351(3):628-637.
Clinical Development:
References-
PubChem:UNII:Literature:
Benoist CC, et al. J Pharmacol Exp Ther. 2014 — HGF/c-Met mechanism; McCoy AT, et al. Neurobiol Learn Mem. 2014 — Synaptogenesis data (Retracted 2025); Athira Pharma: Fosgonimeton (prodrug) pipeline status
Disclaimer:Dihexa is NOT FDA-approved or EMA-approved as a medicine. It is a research compound only. The foundational 2014 paper describing its synaptogenic potency was retracted in 2025. Its phosphate prodrug fosgonimeton failed a Phase 2/3 Alzheimer’s trial (LIFT-AD, 2024). This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.
Hazard IdentificationClassification of the substance or mixture
Eye irritation, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 4
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H319 Causes serious eye irritation
H413 May cause long lasting harmful effects to aquatic life
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
P203 Obtain, read and follow all safety instructions before use.
Response P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
chemicals
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Location:
No.885 Xiahe Road, Siming District, Xiamen City
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A
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Average lead Time:
180
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
11-50
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Year of Establishment:
2007
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Certifications:
ISO,sgs
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Country Product Purchase Quantity Date Posted Post an enquiry for this product