Carperitide Acetate 98% white powder CAS 89213-87-6/ Youngshe
89213-87-6
Chemical Grade
98%
chengdu
Youngshe
Plastic bottle
Yes
2030-12-30
Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediates
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Product Details
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Seller Information
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DescriptionECHEMI Editorial ReferenceAtrial Natriuretic Peptide (ANP) (1-28), human, porcine is a 28-amino acid hormone, that is normally produced and secreted by the human heart in response to cardiac injury and mechanical stretch. ANP (1-28) inhibits endothelin-1 secretion in a dose-dependent way.
Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations.
Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, inhibit renin secretion, and increase sodium excretion. Human ANP binds to ANP receptors on cultured vascular smooth muscle cells (VSMCs) with a Kdvalue of approximately 1-2 nM and increases cGMP levels in a dose-dependent manner. It relaxes potassium-induced contraction of isolated canine renal arterial strips when used at concentrations of 10 and 100 ng/ml and dilates renal arteries in anesthetized dogs when used at doses ranging from 10 to 100 ng/kg. In a rat model of heart failure following experimental autoimmune myocarditis, human ANP,viaosmotic mini pump for 28 days, decreases cardiomyocyte size as well as the amount of cardiac fibrosis and left ventricular remodeling. ANP (1-28) (human) is a 28 amino acid peptide corresponding to the human protein sequence.
ChEBI: Carperitide is a polypeptide.Basic Info-
Product Name:
Carperitide
Other Name:ATRIAL NATRIURETIC PEPTIDE HUMAN;SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET: O-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR[SLRRSSCFGGR-MET: O-DRIGAQSGLGCNSFRY]DISULFIDE BRIDGE CYS7-CYS23.;Carperitide Acetate, carperitida;Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt);ahANF, Carperitide;H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH;Atrial natriureticpeptide-28 (huMan) (9CI);Atrial Natriuretic Factor (1-28) (huMan) αhANF, Carperitide
CAS No.:89213-87-6
Molecular Formula:C127H203N45O39S3
InChIKeys:NSQLIUXCMFBZME-VUEHYBQXNA-N
Molecular Weight:3080.44
Exact Mass:3078.444580
EC Number:686-482-9
Categories:
Characteristics-
PSA:
1479.28000
XLogP3:-14.30
Density:1.55±0.1 g/cm3(Predicted)
Refractive Index:1.689
Critical Temperature & Pressure:Store at -20°C
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Cosmetic peptides,beauty raw materials,custom peptides,pharmaceutical intermediates
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Location:
Unit 12, Building 10, No.77, Tianmu Road, Gaoxin West District, Yi County, Chengdu City, Sichuan Province
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Payment Terms:
TT against copy of documents
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Average lead Time:
7 days
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
11-50
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Year of Establishment:
2015
Company Certificates-
![YoungsheISO9001]( "ISO9001")
ISO9001
Chengdu YoungShe Chemical Co., Ltd is a new and dynamic high-tech enterprise that is constantly innovating and specializing in the development of beauty peptides. The company is headquartered in Chengdu Hi-tech Development Zone. Since its establishment in early 2015, the company has launched hundreds of beauty peptide products with different functions, which are widely sold at home and abroad.
Chengdu Youngshe Chemical Co., Ltd.'s main cosmetic peptide products are dipeptide, tripeptide, tetrapeptide, pentapeptide, hexapeptide, and seven peptides ( heptapeptide, octapptide, nonapeptide, decapeptide, and oligopeptide.
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