ONO-4059(GS-4059,Tirabrutinib) free base
1351636-18-4
99%
Bottle,barrel,cargo,container,etc.
Yes
2026-11-14
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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DescriptionKeywords
1351636-18-4
ONO-4059(GS-4059,Tirabrutinib) free base
Quick DetailsProName:ONO-4059(GS-4059,Tirabrutinib) free base
CasNo:1351636-18-4
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)).|Tirabrutinib is an orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, tirabrutinib covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.Basic Info-
Product Name:
ONO-4059
Other Name:6-amino-9-[(3R)-1-(but-2-ynoyl)pyrrolidin-3-yl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one;BtkKinaseinhibitor;ONOBTK;ONO-4059(GS-4059,TirabrChemicalbookutinib)freebase;6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one;Tirabrutinib(ONO-4059);Tirabrutinib
CAS No.:1351636-18-4
Molecular Formula:C25H22N6O3
InChIKeys:SEJLPXCPMNSRAM-GOSISDBHSA-N
Molecular Weight:454.48
Exact Mass:454.175354
UNII:LXG44NDL2T
NCI Thesaurus Code:C102876
Categories:
Characteristics-
PSA:
105
XLogP3:3
Density:1.4±0.1 g/cm3
Melting Point:172 °C
Boiling Point:672.0±65.0°C at 760 mmHg
Flash Point:360.2±34.3 °C
Refractive Index:1.700
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5 days
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
Company Certificates-
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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