ONO4059
ISO
1351636-18-4
pharmaceutical grade
98%
25kg/Cardboard Drum
Yes
2024-07-18
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceTirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.
Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)).|Tirabrutinib is an orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, tirabrutinib covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.CertificatesBasic Info-
Product Name:
ONO-4059
Other Name:6-amino-9-[(3R)-1-(but-2-ynoyl)pyrrolidin-3-yl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one;BtkKinaseinhibitor;ONOBTK;ONO-4059(GS-4059,TirabrChemicalbookutinib)freebase;6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one;Tirabrutinib(ONO-4059);Tirabrutinib
CAS No.:1351636-18-4
Molecular Formula:C25H22N6O3
InChIKeys:SEJLPXCPMNSRAM-GOSISDBHSA-N
Molecular Weight:454.48
Exact Mass:454.175354
UNII:LXG44NDL2T
NCI Thesaurus Code:C102876
Categories:
Characteristics-
PSA:
105
XLogP3:3
Density:1.4±0.1 g/cm3
Melting Point:172 °C
Boiling Point:672.0±65.0°C at 760 mmHg
Flash Point:360.2±34.3 °C
Refractive Index:1.700
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Location:
Room 507, Dongnan Technology R&D Center, No.438 Jincheng Road, Beigan Street, Xiaoshan District,Hangzhou City,Zhengjiang Province,China
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
20 days
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
51-100
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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