Floxuridine
50-91-9
99%
Bottle,barrel,cargo,container,etc.
2026-09-24
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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DescriptionKeywords
50-91-9
Floxuridine
C9H11FN2O5
Quick DetailsProName:Floxuridine
CasNo:50-91-9
Molecular Formula:C9H11FN2O5
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceFloxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. IC50 value: Target: Nucleoside antimetabolite/analogFloxuridine (Fludara) is a prodrug of floxuridine and an oncology agent with an GI50 of 5.1 μM for the inhibition of MDCK/PEPT1. Floxuridine (Fludara) belongs to the class known as antimetabolites. Floxuridine (Fludara) is most often used in the treatment of colorectal cancer. Flox
Inhibits DNA synthesis. (NTP, 1992)|Solid
Inhibits DNA synthesis. (NTP, 1992)|Floxuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. It has a role as an antineoplastic agent, an antimetabolite, an antiviral drug and a radiosensitizing agent. It is a pyrimidine 2'-deoxyribonucleoside, an organofluorine compound and a nucleoside analogue.|An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.|Floxuridine is an Antimetabolite.|Floxuridine (FUDR) is a pyrimidine analogue used as an antineoplastic agent, usually as a continuous hepatic arterial infusion to treat hepatic metastases from colon cancer. Intraarterial floxuridine is associated with a very high rate of serum enzyme and bilirubin elevations during therapy, and with frequent biliary damage that can result in a secondary sclerosing cholangitis, which can be severe and lead to cirrhosis.|Floxuridine is a fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)|An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.Basic Info-
Product Name:
Floxuridine
Other Name:Uridine,2′-deoxy-5-fluoro-;2′-Deoxy-5-fluorouridine;Floxuridine;5-Fluorodeoxyuridine;5-Fluoro-2′-deoxyuridine;5-Fluorouracil 2′-deoxyriboside;5-Fluorouracil deoxyriboside;NSC 27640;1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2′-deoxy-β-uridine;FUDR;Floxuridin;FdUrd;NSC 26740;5-FudR;888-03-9;3460-74-0
CAS No.:50-91-9
Molecular Formula:C9H11FN2O5
InChIKeys:InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Molecular Weight:246.19
Exact Mass:246.19
BRN:2645818
EC Number:200-072-5
UNII:039LU44I5M
UN Number:1760
DSSTox ID:DTXSID3023057
NCI Thesaurus Code:C504
Color/Form:Crystals from butyl acetate|WHITE TO OFF-WHITE SOLID
ATC Code:L - Antineoplastic and immunomodulating agents
HScode:2934999090
Categories:
Characteristics-
PSA:
99.1
XLogP3:-1.2
Appearance:White to almost white Powder
Density:1.8±0.1 g/cm3
Melting Point:150-151 °C
Boiling Point:150 °C
Flash Point:245.9±31.5 °C
Refractive Index:1.676
Water Solubility:H2O: soluble
Storage Conditions:2-8°C
Vapor Pressure:7.6X10-13 mm Hg at 25 deg C (est)
Toxicity:LD50 oral in rat: 215mg/kg
Specific rotation:35.9 º (c=1, water)
Odor:ODORLESS
PKA:7.44None
Henrys Law Constant:Henry's Law constant = 1.5X10-17 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.44|pKa = 7.44 (imide nitrogen)
Experimental Properties:Hydroxyl radical reaction rate constant = 6.7X10-11 cu cm/molecule-sec at 25 °C (est)|Ozone reaction rate constant = 7.0X10-19 cu cm/molecule-sec at 25 °C (est)
Air and Water Reactions:No rapid reaction with air. No rapid reaction with water.
Reactive Group:Alcohols and Polyols
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Floxuridine sterile powder should be protected from light and stored at 15-30 deg C. In the dry state, floxuridine has an expiration date of 3 years following the date of manufacture. Reconstituted floxuridine injection should be stored at 2-8 deg C and used within 2 weeks.
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
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