Procarbazine hydrochloride
366-70-1
99%
Bottle,barrel,cargo,container,etc.
2026-10-14
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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DescriptionKeywords
Procarbazine hydrochloride
366-70-1
C12H19N3O.HCl
Quick DetailsProName:Procarbazine hydrochloride
CasNo:366-70-1
Molecular Formula:C12H19N3O.HCl
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceProcarbazine Hydrochloride is an alkylating agent, with anticancer activity.
Procarbazine hydrochloride is a white to pale yellow crystalline powder with a slight odor. Acid to litmus. (NTP, 1992)
Procarbazine hydrochloride is a white to pale yellow crystalline powder with a slight odor. Acid to litmus. (NTP, 1992)|Procarbazine hydrochloride is a hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. It has a role as an antineoplastic agent. It contains a procarbazine(1+).|Procarbazine Hydrochloride is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.|An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.Basic Info-
Product Name:
Procarbazine hydrochloride
Other Name:Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-,hydrochloride (1:1);p-Toluamide,N-isopropyl-α-(2-methylhydrazino)-,monohydrochloride;Benzamide,N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-,monohydrochloride;NSC 77213;Ibenzmethyzine hydrochloride;Ibenzmethyzin hydrochloride;IBZ;2-[p-(Isopropylcarbamoyl)benzyl]-1-methylhydrazine hydrochloride;N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride;N-Isopropyl-α-(2-methylhydrazino)-p-toluamide hydrochloride;MBH;1-Methyl-2-[p-(isopropylcarbamoyl)benzyl]hydrazine hydrochloride;Natulan;Natulan hydrochloride;Procarbazine hydrochloride;Ro 4-6467;Matulane;Natulanar;MIH hydrochloride;Ro 4 6467/1;NCI-C 01810;Nathulane;PCB hydrochloride;Indicarb
CAS No.:366-70-1
Molecular Formula:C12H19N3O.ClH
InChIKeys:InChIKey=DERJYEZSLHIUKF-UHFFFAOYSA-N
Molecular Weight:257.76
Exact Mass:257.129486
EC Number:206-678-6
UNII:XH0NPH5ZX8
NSC Number:77213
DSSTox ID:DTXSID3021190
NCI Thesaurus Code:C773
HScode:2928000090
Categories:
Characteristics-
PSA:
53.2
Appearance:white to tan
Density:8.3 g/cm3
Melting Point:223-226 °C
Boiling Point:384.6°C at 760 mmHg
Flash Point:148.9ºC
Water Solubility:H2O: >=10 g/100 mL at 21.5 ºC;DMSO: ≥18mg/mL
Storage Conditions:-20°C Freezer
Vapor Pressure:8.4X10-7 mm Hg @ 25 deg C /Estimated/
Toxicity:LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)
Air and Water Reactions:In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reactive Group:Amides and Imides
Reactivity Profile:PROCARBAZINE HYDROCHLORIDE is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media (NTP, 1992).
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Germ cell mutagenicity, Category 2
Carcinogenicity, Category 1B
Reproductive toxicity, Category 1A
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H302 Harmful if swallowed
H341 Suspected of causing genetic defects
H350 May cause cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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