Deferasirox
2 Inquiries
201530-41-8
99%
Bottle,barrel,cargo,container,etc.
2026-10-05
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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Inquiry History
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DescriptionKeywords
Deferasirox
201530-41-8
C21H15N3O4
Quick DetailsProName:Deferasirox
CasNo:201530-41-8
Molecular Formula:C21H15N3O4
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceDeferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload.
Solid
Deferasirox is a member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions. It has a role as an iron chelator. It is a member of triazoles, a monocarboxylic acid, a member of benzoic acids and a member of phenols. It derives from a 2,2'-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)diphenol.|Deferasirox is an iron chelator and the first oral medication FDA approved for chronic iron overload in patients receiving long term blood transfusions.|Deferasirox is an Iron Chelator. The mechanism of action of deferasirox is as an Iron Chelating Activity, and Cytochrome P450 3A4 Inducer, and Cytochrome P450 2C8 Inhibitor, and Cytochrome P450 1A2 Inhibitor.|Deferasirox is an oral iron chelating agent used to treat chronic iron overload. Deferasirox has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury, which can be severe and even fatal.|Deferasirox is a synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.|A triazole and benzoate derivative that acts as a selective iron chelator. It is used in the management of chronic IRON OVERLOAD due to blood transfusion or non-transfusion dependent THALASSEMIA.Basic Info-
Product Name:
Deferasirox
Other Name:Benzoic acid,4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-;4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid;ICL 670A;ICL 670;Deferasirox;4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid;Exjade;Asunra;Jadenu
CAS No.:201530-41-8
Molecular Formula:C21H15N3O4
InChIKeys:InChIKey=BOFQWVMAQOTZIW-UHFFFAOYSA-N
Molecular Weight:373.3615
Exact Mass:373.36
EC Number:1806241-263-5
UNII:V8G4MOF2V9
DSSTox ID:DTXSID1048596
NCI Thesaurus Code:C48384
Color/Form:Crystals from ethanol|White to slightly yellow powder
ATC Code:V03AC03|V - Various
HScode:2933990090
Categories:
Characteristics-
PSA:
109 Ų
XLogP3:log Kow = 6.30 (pH 7.4)|3.52
Density:1.4±0.1 g/cm3
Melting Point:260-2620C
Boiling Point:651°C at 760 mmHg
Flash Point:360.3±34.3 °C
Refractive Index:1.699
Water Solubility:In water, 0.4 mg/mL at 25 °C (pH 7.40)|3.43e-02 g/L
Storage Conditions:-20°C Freezer
Vapor Pressure:1.67X10-13 mm Hg at 25 °C (est)
Henrys Law Constant:Henry's Law constant = 1.4X10-17 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 4.57; pKa2 = 8.71; pKa3 = 10.56|Dissociation constant also reported in H2O/DMSO (X(DMSO = 0.20) as pKa1 = 4.61; pKa2 = 10.12; pKa3 = 12.08
Experimental Properties:Hydroxyl radical reaction rate constant = 2.05X10-10 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P273 Avoid release to the environment.
Response P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
India
Deferasirox
25 KG Mar 19, 2024 
Hongkong, China
Deferasirox is an iron chelator (binder)
5000 KG May 12, 2025 Post an enquiry for this product