Tolfenamic acid
3 Inquiries
13710-19-5
99%
Bottle,barrel,cargo,container,etc.
2026-10-02
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Product Description
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Seller Information
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Inquiry History
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DescriptionKeywords
13710-19-5
Tolfenamic acid
C14H12ClNO2
Quick DetailsProName:Tolfenamic acid
CasNo:13710-19-5
Molecular Formula:C14H12ClNO2
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceTolfenamic Acid is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibits COX-2, with an IC50 of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect on COX-1.
Solid
Tolfenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 3-chloro-2-methylphenyl group. Tolfenamic acid is used specifically for relieving the pain of migraine. It also shows anticancer activity. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an EC 2.7.1.33 (pantothenate kinase) inhibitor. It is an aminobenzoic acid, an organochlorine compound and a secondary amino compound. It derives from an anthranilic acid.|Tolfenamic acid, with the formula N-(2-methyl-3-chlorphenyl)-anthranilic acid, is a nonsteroidal anti-inflammatory agent. It was discovered by scientists at Medica Pharmaceutical Company in Finland. It is used in the UK as a treatment for migraine under the name of Clotam. In the US, it presents a Status class I by the FDA. By the European Medicine Agency, it was granted in 2016 with the status of orphan for the treatment of supranuclear palsy.|Tolfenamic Acid is an orally available, benzoic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic, analgesic and potential anti-neoplastic activities. Tolfenamic acid inhibits the activity of the enzymes cyclooxygenase (COX) I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The decrease in prostaglandin synthesis results in the therapeutic effects of this agent. Tolfenamic acid also inhibits thromboxane A2 synthesis, by thromboxane synthase, which decreases platelet aggregation. In addition, this agent exerts anti-tumor effects through COX-dependent and independent pathways. Specifically, this agent induces the production of reactive oxygen species, causes DNA damage, increases nuclear factor-kappa B (NF-kB) activation and the expression of activating transcription factor 3 (ATF3) and NSAID-activated gene-1 (NAG1), and inhibits the expression of specificity proteins (Sp), which reduces the expression of Sp-dependent anti-apoptotic and growth-promoting proteins. Altogether, this enhances tumor cell apoptosis, and reduces tumor cell growth and angiogenesis.Basic Info-
Product Name:
Tolfenamic acid
Other Name:Benzoic acid,2-[(3-chloro-2-methylphenyl)amino]-;Anthranilic acid,N-(3-chloro-o-tolyl)-;2-[(3-Chloro-2-methylphenyl)amino]benzoic acid;N-(2-Methyl-3-chlorophenyl)anthranilic acid;N-(3-Chloro-o-tolyl)anthranilic acid;Tolfenamic acid;GEA 6414;Clotam;Tolfedine;Tolfine;Migea;Tolfenamate;2-(3-Chloro-2-methylanilino)benzoic acid
CAS No.:13710-19-5
Molecular Formula:C14H12ClNO2
InChIKeys:InChIKey=YEZNLOUZAIOMLT-UHFFFAOYSA-N
Molecular Weight:261.7
Exact Mass:261.70
EC Number:237-264-3
UNII:3G943U18KM
NSC Number:757873
DSSTox ID:DTXSID1045409
NCI Thesaurus Code:C87328
ATC Code:M - Musculo-skeletal system
HScode:2922499990
Categories:
Characteristics-
PSA:
49.3
XLogP3:5.2
Appearance:Solid
Density:1.3±0.1 g/cm3
Melting Point:207-207.5 °C
Boiling Point:405.4°C at 760 mmHg
Flash Point:199.0±27.3 °C
Refractive Index:1.658
Water Solubility:soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
Storage Conditions:Refrigerator
Vapor Pressure:2.66E-07mmHg at 25°C
PKA:5.11None
Dissociation Constants:5.11
Collision Cross Section:155.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|153.7 Ų [M+H]+ [CCS Type: TW]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
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Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
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Payment Terms:
TT against copy of documents,D/P,L/C
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Average lead Time:
5
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Total Annual Revenue:
Above $100 million
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Year of Establishment:
2020
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Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Vietnam
Tolfenamic acid
2.00 TON Nov 17, 2023 
India
Tolfenamic acid
1 MT Sep 7, 2025 
Bangladesh
Tolfenamic Acid
200 KG Jul 28, 2025 Post an enquiry for this product
