Jublia 99% powder/liquid
3 Inquiries
164650-44-6
99%
SHANGHAI PORT
Bucket
2022-08-01
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
-
Product Details
-
Seller Information
-
Inquiry History
-
DescriptionECHEMI Editorial ReferenceChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes).In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like othe
Efinaconazole is a member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes). It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is an organofluorine compound, an olefinic compound, a member of piperidines, a tertiary alcohol, a tertiary amino compound, a conazole antifungal drug and a triazole antifungal drug.|Efinaconazole is a 14 alpha-demethylase inhibitor indicated in the treatment of fungal infection of the nail, known as onychomycosis. It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North America LLC under the name Jublia.|Efinaconazole is an Azole Antifungal.|Efinaconazole is a triazole compound, with antifungal activity. Upon administration, efinaconazole targets, binds to and inhibits 14-alpha-demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis.Basic Info-
Product Name:
Efinaconazole
Other Name:1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,(αR,βR)-;1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,[R-(R*,R*)]-;(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;KP 103 (pharmaceutical);KP 103;Efinaconazole;Jublia;(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(4H-1,3,4-triazol-4-yl)butan-2-ol
CAS No.:164650-44-6
Molecular Formula:C18H22F2N4O
InChIKeys:InChIKey=NFEZZTICAUWDHU-RDTXWAMCSA-N
Molecular Weight:348.3902864
Exact Mass:348.39
EC Number:1592732-453-0
UNII:J82SB7FXWB
DSSTox ID:DTXSID40167787
NCI Thesaurus Code:C97998
ATC Code:D - Dermatologicals
Categories:
Characteristics-
PSA:
54.2
XLogP3:2
Density:1.26±0.1 g/cm3(Predicted)
Boiling Point:512.2±60.0 °C(Predicted)
Flash Point:263.6±32.9 °C
Refractive Index:1.590
Water Solubility:In water, 321.6 mg/L at 25 °C (est)
Storage Conditions:Store at 20 °C to 25 °C (68 °F to 77 °F); excursions permitted to 15 °C to 30 °C (59 °F to 86 °F).|Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20 °C.
Vapor Pressure:1.57X10-9 mm Hg at 25 °C (est)
Henrys Law Constant:Henry's Law constant = 1.83X10-13 atm-cu m/mol at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 2.17X10-12 cu cm/molecule-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.2X10-17 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
-
Location:
https://www.dideu.com/en/
-
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
-
Average lead Time:
7 days
-
Total Annual Revenue:
Above $100 million
-
Total Employees:
Above 1000
-
Year of Establishment:
2016
Company Certificates-
![Shaanxi Dideu Medichem Co. LtdISO Certificate]( "ISO Certificate")
ISO Certificate
-
![Shaanxi Dideu Medichem Co. LtdREACH]( "REACH")
REACH
">Company Profile -
-
Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Hungary
Efinaconazole
5 PCS May 1, 2026 
United States
Efinaconazole
1 KG Jan 28, 2026 
Bangladesh
Efinaconazole
12 KG May 16, 2025 Post an enquiry for this product
More from this Seller
-
-
![5-Chloro-3-(piperidin-1-ylsulfonyl)pyridin-2-amine]( "5-Chloro-3-(piperidin-1-ylsulfonyl)pyridin-2-amine")
-
5-Chloro-3-(piperidin-1-ylsulfonyl)pyridin-2-amine
Industrial Grade / 99%
-
-
-
![1,2-Pentanediol 99% liquid Dideu]( "1,2-Pentanediol 99% liquid Dideu")
-
1,2-Pentanediol 99% liquid Dideu
Industrial Grade / 99%
-
-
-
![Pyridoxal-5-Phosphate PLP P5P 99% White Crystalline Powder Dideu]( "Pyridoxal-5-Phosphate PLP P5P 99% White Crystalline Powder Dideu")
-
Pyridoxal-5-Phosphate PLP P5P 99% White Crystalline Powder Dideu
Pharmaceutical Grade / 99%
-
-
-
![2,2'-Azobis(2-methylpropionitrile) 99% Dideu]( "2,2'-Azobis(2-methylpropionitrile) 99% Dideu")
-
2,2'-Azobis(2-methylpropionitrile) 99% Dideu
Industrial Grade / 99%
-
![2-Pyridinamine,4-[4-(4-fluorophenyl)-2-(methylthio)-1-(2,2,6,6-tetramethyl-4-piperidinyl)-1H-imidazol-5-yl]- 90% 222-1-w Dideu;CT200](https://file.echemi.com/fileManage/upload/goodpicture/20230417/m20230417110500636.jpg "2-Pyridinamine,4-[4-(4-fluorophenyl)-2-(methylthio)-1-(2,2,6,6-tetramethyl-4-piperidinyl)-1H-imidazol-5-yl]- 90% 222-1-w Dideu;CT200")
