KP 103
3 Inquiries
164650-44-6
99%
Bottle,barrel,cargo,container,etc.
Yes
2026-11-25
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Product Details
-
Seller Information
-
Inquiry History
-
DescriptionKeywords
KP 103
164650-44-6
Quick DetailsProName:KP 103
CasNo:164650-44-6
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceChEBI: A member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes).In October 2013, efinaconazole (also known as KP-103) was approved in Canada as a 10% topical solution for the treatment of onychomycosis. Like othe
Efinaconazole is a member of the class of triazoles that is butan-2-ol which is substituted at positions 1, 2, and 3 by 1,2,4-triazol-1-yl, 2,4-difluorophenyl, and 4-methylenepiperidin-1-yl groups, respectively (the 2R,3R stereoisomer). It is an antifungal drug used for the topical treatment of onychomycosis (a nail infection caused mainly by dermatophytes). It has a role as an EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor. It is an organofluorine compound, an olefinic compound, a member of piperidines, a tertiary alcohol, a tertiary amino compound, a conazole antifungal drug and a triazole antifungal drug.|Efinaconazole is a 14 alpha-demethylase inhibitor indicated in the treatment of fungal infection of the nail, known as onychomycosis. It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North America LLC under the name Jublia.|Efinaconazole is an Azole Antifungal.|Efinaconazole is a triazole compound, with antifungal activity. Upon administration, efinaconazole targets, binds to and inhibits 14-alpha-demethylase, a cytochrome P450-dependent enzyme. Inhibition of 14-alpha-demethylase prevents the conversion of lanosterol to ergosterol, an important component of the fungal cell wall. Inhibition of ergosterol synthesis changes the fungal cell membrane composition and integrity, alters membrane permeability and eventually leads to fungal cell lysis.Basic Info-
Product Name:
Efinaconazole
Other Name:1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,(αR,βR)-;1-Piperidineethanol,α-(2,4-difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-,[R-(R*,R*)]-;(αR,βR)-α-(2,4-Difluorophenyl)-β-methyl-4-methylene-α-(1H-1,2,4-triazol-1-ylmethyl)-1-piperidineethanol;KP 103 (pharmaceutical);KP 103;Efinaconazole;Jublia;(2R,3R)-2-(2,4-Difluorophenyl)-3-(4-methylenepiperidin-1-yl)-1-(4H-1,3,4-triazol-4-yl)butan-2-ol
CAS No.:164650-44-6
Molecular Formula:C18H22F2N4O
InChIKeys:InChIKey=NFEZZTICAUWDHU-RDTXWAMCSA-N
Molecular Weight:348.3902864
Exact Mass:348.39
EC Number:1592732-453-0
UNII:J82SB7FXWB
DSSTox ID:DTXSID40167787
NCI Thesaurus Code:C97998
ATC Code:D - Dermatologicals
Categories:
Characteristics-
PSA:
54.2
XLogP3:2
Density:1.26±0.1 g/cm3(Predicted)
Boiling Point:512.2±60.0 °C(Predicted)
Flash Point:263.6±32.9 °C
Refractive Index:1.590
Water Solubility:In water, 321.6 mg/L at 25 °C (est)
Storage Conditions:Store at 20 °C to 25 °C (68 °F to 77 °F); excursions permitted to 15 °C to 30 °C (59 °F to 86 °F).|Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature -20 °C.
Vapor Pressure:1.57X10-9 mm Hg at 25 °C (est)
Henrys Law Constant:Henry's Law constant = 1.83X10-13 atm-cu m/mol at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 2.17X10-12 cu cm/molecule-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.2X10-17 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Reproductive toxicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H361 Suspected of damaging fertility or the unborn child
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
-
Payment Terms:
TT against copy of documents,D/P,L/C
-
Average lead Time:
5 days
-
Total Annual Revenue:
Above $100 million
-
Year of Establishment:
2020
Company Certificates-
![HANGZHOU LEAP CHEM CO., LTD.ISO]( "ISO")
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
-
-
Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted 
Bangladesh
Efinaconazole
12 KG May 16, 2025 
Hungary
Efinaconazole
5 PCS May 1, 2026 
United States
Efinaconazole
1 KG Jan 28, 2026 Post an enquiry for this product
More from this Seller
-
-
![Pigment Violet 19]( "Pigment Violet 19")
-
Pigment Violet 19
/ 99.00%
-
-
-
![Methoxyammonium chloride]( "Methoxyammonium chloride")
-
Methoxyammonium chloride
/ 99.00%
-
-
-
![5-Methyl furfural]( "5-Methyl furfural")
-
5-Methyl furfural
/ 99.00%
-
-
-
![N,N-Dibutylformamide]( "N,N-Dibutylformamide")
-
N,N-Dibutylformamide
/ 99.00%
-
-
-
![5-Thymidylic acid disodium salt]( "5-Thymidylic acid disodium salt")
-
5-Thymidylic acid disodium salt
/ 99.00%
-
-
-
![Raltegravir potassium]( "Raltegravir potassium")
-
Raltegravir potassium
/ 99.00%
-
