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Acalabrutinib 98% white powder 1420477-60-6 Senwayer

Name: Acalabrutinib 98% white powder 1420477-60-6 Senwayer
Brand: Senwayer
SKU: pr2209091274
Price: 25000 USD
Availability: InStock

4 Inquiries

Unit Price: Get Latest Price 

CAS No.:

1420477-60-6

Grade:

Pharmaceutical Grade

Content:

98%

Port:

shanghai

Brand:

Senwayer

Packaging:

500g/ bag 25kg/ drum

Sample Available:

Yes

Price valid (until):

2023-07-21

Contact Supplier

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C

Average Lead Time:

10 days

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Information

Acalabrutinib blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells.

Acalabrutinib is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. acalabrutinib is given after other treatments have failed.

Acalabrutinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, patients responded to this medicine. However, further studies are needed.

Product name	Acalabrutinib
CAS No.	1420477-60-6
MF	C26H23N7O2
MW	465.51
EINECS No,	814-272-0
Melting point	>133°C (dec.)
Boiling point	N/A
Density	1.37±0.1 g/cm3(Predicted)
Solubility	Soluble in DMSO (up to at least 25 mg/ml)
Storage	Refrigerator

About us

Wuhan senwayer century chemical Co.,Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.
If you are interested, pls contact me freely!

ECHEMI Editorial Reference

Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
ChEBI: Acalabrutinib is a member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a member of pyridines, an aromatic amine, a pyrrolidinecarboxamide, an imidazopyrazine, a ynone and a tertiary carboxamide.
Class: non-receptor tyrosine kinaseTreatment: CLL, SLL, MCLOral bioavailability = 25%Elimination half-life = 0.9 hProtein binding = 97.5%

Basic Info

Product Name:

Acalabrutinib

Other Name:

ACP196;ACP-196;acalabrutinib;Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-;ACP196,Acalabrutinib;4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide;EOS-60753;(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

CAS No.:

1420477-60-6

Molecular Formula:

C26H23N7O2

InChIKeys:

WDENQIQQYWYTPO-IBGZPJMESA-N

Molecular Weight:

465.51

Exact Mass:

465.51

EC Number:

814-272-0

Color/Form:

Yellow

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.37±0.1 g/cm3(Predicted)

Melting Point:

>133°C (dec.)

PKA:

11.47±0.70(Predicted)

Critical Temperature & Pressure:

Refrigerator

See More Acalabrutinib Properties 

Hazard Identification

Classification of the substance or mixture

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P319 Get medical help if you feel unwell.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Acalabrutinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10 days

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- Verified supplier certificate
- SGS
Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Acalabrutinib	11 KG	Apr 21, 2025
India	ACALABRUTINIB	1 KG	Jun 4, 2025
Pakistan	Acalabrutinib	1 KG	Jun 18, 2025
India	Acalabrutinib	10 KG	Apr 14, 2025

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Acalabrutinib 98% white powder 1420477-60-6 Senwayer

Product Description

Seller Information