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High Quality 99% Acalabrutinib CAS 1420477-60-6

Name: High Quality 99% Acalabrutinib CAS 1420477-60-6
Brand: HyperChem
SKU: pr2505271048
Price: 13000 USD
Availability: InStock

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CAS No.:

1420477-60-6

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

HANGZHOU

Brand:

HyperChem

Packaging:

500g/ bag 25kg/ drum

Sample Available:

Yes

Price valid (until):

2025-06-27

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Acalabrutinib
CAS number	1420477-60-6
Synonym	ACP-196; ACP196; ACP 196; Acalabrutinib.
Related CAS	1420477-60-6 (free base); 2242394-65-4 (maleate); 2058091-93-1 (3 hydrate); 2058091-94-2 (fumarate); 2058091-96-4 (phosphate); 2058091-99-7 (citrate); 2058091-97-5 (tartrate); 2058092-05-8 (sulfate).
Description	Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Structure
Molecular Formula	C₂₆H₂₃N₇O₂
Molecular Weight	465.52 g/mol
	White to light yellow powder
Quality Standard	Enterprise standard
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Acalabrutinib More Info

Acalabrutinib is a novel second-generation Bruton tyrosine kinase (BTK) inhibitor primarily used for the treatment of B-cell malignancies such as chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). It works by selectively inhibiting BTK activity, blocking the B-cell receptor signaling pathway, thereby inhibiting cancer cell proliferation and survival. It is characterized by high efficiency, strong selectivity, and fewer side effects.

Product Advantages

High Selectivity: Acalabrutinib has high selectivity for BTK with minimal cross-inhibition of other kinases such as EGFR, TEC, or ITK, reducing side effects from non-specific inhibition.

High Efficiency: Demonstrates significant anti-tumor activity in clinical trials, rapidly reducing tumor burden and extending patient survival.

Good Tolerability: Compared to first-generation BTK inhibitors, Acalabrutinib has lower cardiovascular and gastrointestinal toxicity with better patient tolerability.

Reliable Quality: Produced strictly according to GMP standards to ensure product quality and stability.

Usage and Dosage

Usage: Oral administration twice daily at 100mg per dose; can be taken before or after meals. Capsules should be swallowed whole without chewing, crushing or opening them.

Dosage: The specific dosage should be adjusted based on the patient's condition, weight, liver and kidney function among other factors by doctors following clinical guidelines and individualized treatment plans .

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance

LC at sight

DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.

For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express

FedEx UPS DHL EMS

Fast: 3-7 days around, high cost, door to door service

By Air

Suitable for more than 50kg

Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea

Suitable for more than 500kg

Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:

After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)

2. Packaging photo

3. COA, MSDS, etc

4. Dispatch date & Estimated arriving time

5. Shipping invoice

For commercial orders

A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals

Nutrition Ingredients/ Dietary supplements

Cosmetic Ingredients

Food Ingredients

Veterinary API

Agriculture fertilizer

Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.
ChEBI: Acalabrutinib is a member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazine substituted by 4-(pyridin-2-ylcarbamoyl)phenyl, (2S)-1-(but-2-ynoyl)pyrrolidin-2-yl, and amino groups at positions 1, 3 and 8, respectively. It is an irreversible second-generation Bruton's tyrosine kinase (BTK) inhibitor that is approved by the FDA for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a member of pyridines, an aromatic amine, a pyrrolidinecarboxamide, an imidazopyrazine, a ynone and a tertiary carboxamide.
Class: non-receptor tyrosine kinaseTreatment: CLL, SLL, MCLOral bioavailability = 25%Elimination half-life = 0.9 hProtein binding = 97.5%

Certificates

Basic Info

Product Name:

Acalabrutinib

Other Name:

ACP196;ACP-196;acalabrutinib;Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-;ACP196,Acalabrutinib;4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide;EOS-60753;(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

CAS No.:

1420477-60-6

Molecular Formula:

C26H23N7O2

InChIKeys:

WDENQIQQYWYTPO-IBGZPJMESA-N

Molecular Weight:

465.51

Exact Mass:

465.51

EC Number:

814-272-0

Color/Form:

Yellow

Categories:

Hormones and the Endocrine System

Characteristics

Density:

1.37±0.1 g/cm3(Predicted)

Melting Point:

>133°C (dec.)

PKA:

11.47±0.70(Predicted)

Critical Temperature & Pressure:

Refrigerator

See More Acalabrutinib Properties 

Hazard Identification

Classification of the substance or mixture

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P319 Get medical help if you feel unwell.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Acalabrutinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	ACALABRUTINIB	1 KG	Jun 4, 2025
India	Acalabrutinib	11 KG	Apr 21, 2025
Pakistan	Acalabrutinib	1 KG	Jun 18, 2025
India	Acalabrutinib	10 KG	Apr 14, 2025

Post an enquiry for this product

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High Quality 99% Acalabrutinib CAS 1420477-60-6

Product Description

Seller Information