Cabozantinib

Mode of Action:In vitro biochemical and (or) cytology analysis shows that card Po for, inhibit RET hepatocyte growth factor receptor (humanhepatocytegrowthfactorreceptor, MET) Vascular endothelial generated factor receptor 1 (Vascularendothelialgrowthfactorreceptor1, VEGFR - 1) VEGFR VEGFR - 2-3 stem cell growth factor receptor (KIT) stemcellfactorreceptor, Tyrosine kinase receptor tyrosine kinase (receptortyrosinekinase, TRKB) FMS sample 3 (FMS - likeChemicalbooktyrosinekinase - 3, PLT - 3) AXL and epidermal growth factor domain tyrosine kinase 2 (humantyrosinekinasewithimmunoglobulinlikeandEGF - likedomains2, TIE - 2) tyrosine kinase activity, the above kinase receptor in normal cells and tumor cell growth process are emphatically To function, the abnormal receptor expression in a variety of play an important role in the process of the development of tumor, including inhibition of tumor cell apoptosis, involved in angiogenesis and tumor pathological process, etc Card Po for, by inhibiting the kinase activity and play a role of anti-tumor, kill tumor cells, reduce transfer and inhibiting tumor angiogenesis.